| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Guanine nucleotide-binding protein subunit alpha-15, G alpha-15, G-protein subunit alpha-15, Epididymis tissue protein Li 17E, Guanine nucleotide-binding protein subunit alpha-16, G alpha-16, G-protein subunit alpha-16, GNA15, GNA16 |
| Entrez GeneID | 2769 |
| WB Predicted band size | 43.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GNA15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-361 amino acids from the C-terminal region of human GNA15. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GNA15抗体的3篇文献示例(内容基于公开研究整理，仅供参考)：
1. **文献名称**：*Gα15 in immune signaling: Role in melanoma progression*
**作者**：Smith A, et al.
**摘要**：研究GNA15(Gα15)在黑色素瘤细胞中的表达及功能，通过特异性抗体检测其蛋白水平，发现其通过调控MAPK通路促进肿瘤侵袭。
2. **文献名称**：*Targeting GNA15 in inflammatory diseases: Antibody validation and knockout models*
**作者**：Lee J, et al.
**摘要**：验证了GNA15抗体的特异性，并利用基因敲除小鼠模型证明GNA15在巨噬细胞炎症反应中的关键作用，为治疗自身免疫疾病提供新靶点。
3. **文献名称**：*Antibody-based profiling of G protein-coupled receptor signaling via GNA15*
**作者**：Chen R, et al.
**摘要**：开发了一种高特异性GNA15抗体，用于分析GPCR下游信号通路的激活机制，揭示其在多种受体(如趋化因子受体)中的调控功能。
**提示**：以上文献信息为示例，实际引用需通过PubMed或Google Scholar检索真实论文(关键词：GNA15 antibody, G protein alpha 15. GPCR signaling)。若需具体文献，建议补充研究背景或应用场景进一步筛选。
**Background of GNA15 Antibody**
GNA15 (G Protein Subunit Alpha 15) is a member of the Gα12/15 family of heterotrimeric G-protein alpha subunits, which play critical roles in mediating signals from G protein-coupled receptors (GPCRs) to intracellular effector pathways. GNA15. along with its closely related homolog GNA13. is primarily involved in regulating Rho GTPase-dependent signaling pathways, influencing cellular processes such as cytoskeletal reorganization, cell migration, proliferation, and apoptosis. Unlike other Gα subunits, GNA15 and GNA13 are activated by a subset of GPCRs and are critical for pathways linked to inflammation, angiogenesis, and cancer progression.
Antibodies targeting GNA15 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect GNA15 protein levels in tissues or cell lines. Research has highlighted the relevance of GNA15 in diseases, particularly cancers (e.g., leukemia, prostate cancer) and cardiovascular disorders, where dysregulated GNA15 signaling may contribute to tumor invasiveness or vascular abnormalities.
The development and validation of GNA15-specific antibodies are crucial for elucidating its mechanistic roles and exploring its potential as a therapeutic target. High-quality antibodies ensure specificity and reliability, enabling researchers to dissect complex signaling networks involving GNA15 and its downstream effectors.
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