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Rabbit Polyclonal CEPT1(N-term) Antibody

  • 中文名: CEPT1 (N-term)抗体
  • 别    名: Choline/ethanolaminephosphotransferase 1, hCEPT1, CEPT1
货号: IPDX33690
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于CEPT1(N端)抗体的3篇示例参考文献(注:因文献检索条件限制,以下内容为模拟示例,具体文献需根据实际数据库查询验证):

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1. **文献名称**: *Characterization of CEPT1 N-terminal antibody in lipid metabolism studies*

**作者**: Smith J, et al.

**摘要**: 本研究验证了针对CEPT1蛋白N端的多克隆抗体的特异性,通过Western blot和免疫荧光证实其在哺乳动物细胞中检测内源性CEPT1的表达,并应用于探究CEPT1在磷脂合成中的功能调控。

2. **文献名称**: *Development of a novel monoclonal antibody targeting the N-terminus of human CEPT1*

**作者**: Lee H, et al.

**摘要**: 报道了一种新型CEPT1-Nterm单克隆抗体的开发,通过肽段免疫和杂交瘤筛选获得,验证其对重组和天然CEPT1蛋白的高亲和力,应用于肝癌细胞系中CEPT1蛋白定位研究。

3. **文献名称**: *Role of CEPT1 in ER membrane dynamics revealed by N-terminal specific antibody*

**作者**: Garcia R, et al.

**摘要**: 利用CEPT1-Nterm抗体研究内质网膜脂质转运机制,发现CEPT1的N端结构域对酶活性及亚细胞定位的关键作用,抗体特异性通过siRNA敲降实验确认。

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**注意**:以上文献信息为模拟生成,实际研究中建议通过PubMed、Google Scholar或抗体供应商(如CST、Abcam)的产品引用文献获取准确信息。若研究较少,可关注CEPT1功能相关的论文中抗体使用部分。

背景信息

The CEPT1 (N-term) antibody is designed to target the N-terminal region of choline/ethanolamine phosphotransferase 1 (CEPT1), a key enzyme in phospholipid biosynthesis. CEPT1. also known as SELENOI, catalyzes the final step in the Kennedy pathway, transferring phosphocholine or phosphoethanolamine to diacylglycerol to produce phosphatidylcholine (PC) or phosphatidylethanolamine (PE), respectively. These phospholipids are essential for membrane structure, cell signaling, and lipid metabolism. The N-terminal domain of CEPT1 is critical for its enzymatic activity and interaction with endoplasmic reticulum membranes, where the protein is predominantly localized.

Antibodies against the N-terminal region of CEPT1 are widely used in research to study its expression, localization, and regulatory mechanisms in cellular and disease contexts. They are employed in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate CEPT1's role in physiological processes like membrane biogenesis, lipoprotein assembly, and neuronal development. Dysregulation of CEPT1 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making this antibody a valuable tool for exploring lipid metabolism-related pathologies. Its specificity for the N-terminus ensures recognition of full-length, functional CEPT1. aiding in distinguishing it from truncated isoforms or degradation products.

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