| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-alpha-acetyltransferase 25, NatB auxiliary subunit, Mitochondrial distribution and morphology protein 20, N-terminal acetyltransferase B complex subunit MDM20, NatB complex subunit MDM20, N-terminal acetyltransferase B complex subunit NAA25, p120, NAA25, C12orf30, MDM20, NAP1 |
| Entrez GeneID | 80018 |
| WB Predicted band size | 112.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This C12orf30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 720-748 amino acids from the Central region of human C12orf30. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **C12orf30(TIGAR)抗体** 的示例参考文献(内容为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**: *"TIGAR Antibody-Based Detection of Oxidative Stress Response in Colorectal Cancer"*
**作者**: Smith A, et al.
**摘要**: 研究利用抗C12orf30(TIGAR)抗体验证其在结直肠癌细胞中的表达，证明TIGAR通过调节NADPH水平抑制氧化应激，并与化疗耐药性相关。
2. **文献名称**: *"Development of a Monoclonal Antibody Against Human C12orf30 for Immunohistochemical Applications"*
**作者**: Lee J, et al.
**摘要**: 报道了一种新型C12orf30单克隆抗体的开发，通过免疫组化分析其在正常组织和乳腺癌组织中的差异表达，提示其作为肿瘤标志物的潜力。
3. **文献名称**: *"C12orf30/TIGAR Interaction with p53: Insights from Co-Immunoprecipitation Studies"*
**作者**: Wang Y, et al.
**摘要**: 使用C12orf30抗体进行免疫共沉淀实验，揭示TIGAR与p53蛋白的相互作用机制，及其在DNA损伤修复通路中的调控作用。
4. **文献名称**: *"C12orf30 Antibody Validation in Neurodegenerative Disease Models"*
**作者**: Garcia R, et al.
**摘要**: 验证C12orf30抗体在小鼠脑组织中的特异性，发现TIGAR在阿尔茨海默病模型中表达上调，可能与神经元存活相关。
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**注意**：以上文献为模拟示例，实际研究中请通过 **PubMed、Web of Science** 或 **Google Scholar** 等平台以关键词“C12orf30 antibody”或“TIGAR antibody”检索最新文献。
The C12orf30 antibody targets the protein encoded by the C12orf30 gene (Chromosome 12 Open Reading Frame 30), also known as TAGAP (T-cell activation Rho GTPase-activating protein). This gene is implicated in immune regulation, particularly in T-cell activation and cytoskeletal reorganization. TAGAP contains a conserved RhoGAP domain, suggesting a role in modulating small GTPases like RhoA, which are critical for cell motility and signaling.
C12orf30 gained attention due to genome-wide association studies (GWAS) linking it to autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and celiac disease. These findings highlight its potential involvement in dysregulated immune responses. The C12orf30 antibody is primarily used in research to study protein expression, localization, and function in immune cells. It aids in elucidating TAGAP's interaction networks and its contribution to disease mechanisms, such as aberrant T-cell activation or inflammation.
Available as monoclonal or polyclonal variants, this antibody is validated for techniques like Western blotting, immunohistochemistry, and flow cytometry. Its development supports translational studies aiming to identify therapeutic targets for autoimmune disorders. Ongoing research focuses on clarifying TAGAP's precise molecular pathways and its role as a biomarker or modulator of immune activity.
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