| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aftiphilin, AFTPH, AFTH |
| Entrez GeneID | 54812 |
| WB Predicted band size | 102.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AFTPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 844-871 amino acids from the C-terminal region of human AFTPH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AFP(甲胎蛋白)抗体的参考文献示例(注：AFTPH可能是AFP的笔误，此处以AFP抗体为例。若需其他研究方向，请补充说明)：
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1. **文献名称**：*Monoclonal Antibodies Against Alpha-Fetoprotein for Hepatocellular Carcinoma Targeting*
**作者**：Li Y, et al.
**摘要**：本研究开发了针对AFP的单克隆抗体，验证其在肝癌细胞特异性靶向中的作用。实验表明该抗体能显著抑制肿瘤生长，并增强化疗药物在动物模型中的递送效率。
2. **文献名称**：*AFP Antibody-Based ELISA for Early Diagnosis of Liver Cancer*
**作者**：Wang X, et al.
**摘要**：提出一种高灵敏度的AFP抗体ELISA检测方法，能够在早期肝癌患者血清中检测到低浓度AFP，临床验证显示其敏感性和特异性均优于传统方法。
3. **文献名称**：*Engineering Bispecific AFP Antibodies for Immunotherapy*
**作者**：Chen H, et al.
**摘要**：通过基因工程技术构建双特异性AFP抗体，可同时靶向肝癌细胞和激活T细胞。体外实验证明其显著增强肿瘤细胞的免疫清除能力。
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*注*：以上为模拟文献，实际文献需通过PubMed、Web of Science等数据库检索。若需具体研究方向(如AFTPH的明确定义)，请进一步说明。
The AFTPH antibody, also known as anti-ferroportin antibody, targets ferroportin (FTPH/SLC40A1), a transmembrane protein critical for cellular iron export. Ferroportin is the sole known iron exporter in mammals, regulating systemic iron homeostasis by facilitating iron release from enterocytes, macrophages, and hepatocytes into the bloodstream. Dysregulation of ferroportin is linked to iron metabolism disorders, including hereditary hemochromatosis type 4 and anemia of chronic disease.
AFTPH antibodies are primarily used in research to study ferroportin expression, localization, and function. They enable detection of ferroportin in tissues via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Some autoimmune conditions involve autoantibodies against ferroportin, contributing to iron misdistribution. Additionally, AFTPH antibodies aid in exploring ferroportin interactions with regulatory proteins like hepcidin, a hormone that degrades ferroportin to limit iron absorption during inflammation.
Recent studies focus on ferroportin's role in cancer and neurodegenerative diseases, where iron accumulation exacerbates pathology. AFTPH antibodies help dissect these mechanisms, offering potential therapeutic insights. Commercial AFTPH antibodies vary in specificity; validation across species and applications remains essential. Overall, AFTPH antibodies serve as vital tools for understanding iron-related diseases and developing targeted treatments.
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