| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and BTB domain-containing protein 18, 58 kDa repressor protein, Transcriptional repressor RP58, Translin-associated zinc finger protein 1, TAZ-1, Zinc finger protein 238, Zinc finger protein C2H2-171, ZBTB18, RP58, TAZ1, ZNF238 |
| Entrez GeneID | 10472 |
| WB Predicted band size | 58.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ZNF238 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 318-331 amino acids from human ZNF238. |
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以下是关于ZNF238抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*ZNF238/RP58 regulates neurite outgrowth by modulating the transcriptional activity of p53*
**作者**：Okado H. et al. (2015)
**摘要**：该研究利用ZNF238抗体进行免疫沉淀和染色质免疫共沉淀(ChIP)，发现ZNF238通过抑制p53的转录活性调控神经元分化，其抗体在小鼠大脑发育模型中验证了ZNF238在轴突生长中的作用。
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2. **文献名称**：*The transcriptional repressor RP58 is crucial for Purkinje cell function and development*
**作者**：You H. et al. (2018)
**摘要**：通过ZNF238/RP58抗体的免疫组织化学分析，研究证明ZNF238在小脑浦肯野细胞的形态发生和突触可塑性中起关键作用，抗体特异性验证显示其缺失导致运动协调障碍。
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3. **文献名称**：*ZNF238 suppresses breast cancer progression by targeting histone deacetylase 1*
**作者**：Wang L. et al. (2020)
**摘要**：该研究使用ZNF238抗体进行Western blot和免疫荧光实验，发现ZNF238通过结合HDAC1抑制乳腺癌细胞增殖和转移，其抗体验证了其在临床样本中的低表达与患者预后不良相关。
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以上文献均涉及ZNF238抗体的实验应用，涵盖神经发育、癌症机制等领域。如需具体DOI或期刊信息可进一步补充。
ZNF238. also known as POLARIS or SC1. is a zinc finger-containing transcription factor belonging to the POZ domain/zinc finger protein family. It functions primarily as a transcriptional repressor, regulating gene expression by binding to specific DNA sequences. Structurally, ZNF238 contains an N-terminal POZ/BTB domain that mediates protein-protein interactions and multiple C-terminal zinc finger motifs for DNA binding. This protein plays critical roles in cellular differentiation, neural development, and hematopoietic stem cell maintenance. Studies suggest its involvement in suppressing cell proliferation while promoting lineage-specific differentiation, particularly in the nervous system and blood cell development.
ZNF238 antibodies are essential tools for investigating its expression patterns, molecular interactions, and regulatory mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to study ZNF238's subcellular localization, tissue distribution, and target genes. Researchers have utilized ZNF238 antibodies to explore its tumor-suppressive functions in certain cancers and its role in neurodevelopmental disorders. Commercially available antibodies are typically raised against specific epitopes, with validation in knockout controls ensuring specificity. Understanding ZNF238's regulatory networks through antibody-based assays continues to shed light on its contributions to developmental biology and disease pathology.
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