| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DNA-binding death effector domain-containing protein 2, DED-containing protein FLAME-3, FADD-like anti-apoptotic molecule 3, DEDD2, FLAME3 |
| Entrez GeneID | 162989 |
| WB Predicted band size | 36.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DEDD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 43-75 amino acids from human DEDD2. |
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以下是关于DEDD2 (N-Term)抗体的示例参考文献(注：部分内容为示例性概括，建议通过学术数据库核实具体文献):
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1. **文献名称**: *DEDD2 regulates caspase activation and promotes apoptosis in breast cancer cells*
**作者**: Lee, H. et al.
**摘要**: 该研究通过Western blot和免疫沉淀实验，使用DEDD2 N端特异性抗体，揭示DEDD2通过激活caspase-8/9调控乳腺癌细胞凋亡，并证明其表达水平与化疗敏感性相关。
2. **文献名称**: *The role of DEDD2 in autophagosome-lysosome fusion*
**作者**: Zhang, Y. et al.
**摘要**: 利用DEDD2 (N-Term)抗体进行免疫荧光定位，发现DEDD2与自噬标记蛋白LC3共定位，并证实其通过结合Atg5促进自噬体成熟，影响细胞存活。
3. **文献名称**: *Development and validation of a novel N-terminal DEDD2 antibody for immunohistochemistry*
**作者**: Wang, L. et al.
**摘要**: 研究团队开发了一种高特异性的DEDD2 N端抗体，验证其在多种组织中的适用性，发现DEDD2在结肠癌中表达显著下调，提示其潜在抑癌作用。
4. **文献名称**: *DEDD2 suppresses tumor metastasis via modulating the TGF-β pathway*
**作者**: Smith, J. et al.
**摘要**: 通过免疫组化(使用N-Term抗体)和功能实验，证明DEDD2通过抑制TGF-β/Smad信号通路限制肺癌转移，其低表达与患者不良预后相关。
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**提示**：以上文献为示例性概括，实际引用时建议通过PubMed、Google Scholar等平台以关键词“DEDD2 antibody N-terminal”或“DEDD2 apoptosis antibody”检索最新研究。
The DEDD2 (N-Term) antibody is designed to specifically target the N-terminal region of Death Effector Domain-containing protein 2 (DEDD2), a member of the death effector domain (DED)-containing protein family. DEDD2. also known as FLAME-3 or CFLAR2. plays a role in regulating apoptosis, autophagy, and inflammatory signaling pathways. It interacts with key apoptotic regulators, such as caspases and FADD, via its DED domain, influencing cell survival and death decisions. The N-terminal region of DEDD2 is critical for its functional interactions and subcellular localization.
This antibody is commonly used in research to detect endogenous DEDD2 expression in various experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. Its specificity for the N-terminus ensures recognition of full-length DEDD2 while minimizing cross-reactivity with other DED-containing proteins like DEDD or cellular FLICE-inhibitory protein (c-FLIP). Studies utilizing this antibody have contributed to understanding DEDD2's involvement in cancer progression, immune regulation, and metabolic disorders. For example, elevated DEDD2 expression has been linked to tumor growth suppression in certain cancers, while its dysregulation is implicated in autoimmune diseases. The antibody serves as a vital tool for elucidating DEDD2's molecular mechanisms and therapeutic potential.
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