| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Doublesex- and mab-3-related transcription factor 2, Doublesex-like 2 protein, DSXL-2, DMRT2, DSXL2 |
| Entrez GeneID | 10655 |
| WB Predicted band size | 61.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DMRT2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 357-392 amino acids from the Central region of human DMRT2. |
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以下是3篇涉及DMRT2抗体应用的参考文献示例(注：部分文献信息为示例性虚构，实际引用请核实原文)：
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1. **文献名称**：*DMRT2 regulates skeletal muscle development via chromatin remodeling*
**作者**：Chen et al. (2018)
**摘要**：本研究利用DMRT2特异性抗体，通过免疫组化和Western blot技术，发现DMRT2在小鼠胚胎骨骼肌形成中调控肌细胞分化的关键作用。抗体验证显示其在肌节形成阶段高表达，并通过染色质修饰影响下游靶基因。
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2. **文献名称**：*DMRT2 is required for zebrafish somitogenesis*
**作者**：Smith & Tanaka (2020)
**摘要**：通过CRISPR敲除和DMRT2抗体免疫荧光分析，揭示了DMRT2在斑马鱼体节分节中的必要性。研究发现DMRT2蛋白在体节前体细胞中动态表达，并调控Notch信号通路相关基因。
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3. **文献名称**：*Aberrant DMRT2 expression correlates with poor prognosis in rhabdomyosarcoma*
**作者**：Garcia et al. (2021)
**摘要**：使用DMRT2抗体对横纹肌肉瘤组织进行免疫组化分析，发现DMRT2蛋白高表达与肿瘤侵袭性和患者生存率降低显著相关。提示其作为潜在生物标志物的价值。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“DMRT2 antibody”、“DMRT2 immunohistochemistry”等，并筛选方法学中明确提及该抗体的研究。
The DMRT2 (Doublesex and Mab-3 Related Transcription factor 2) antibody is a tool used to study the DMRT2 protein, a member of the evolutionarily conserved DMRT family of transcription factors. These proteins play critical roles in vertebrate development, particularly in sex determination, gonadal differentiation, and somatic tissue patterning. DMRT2 is involved in somitogenesis, left-right symmetry establishment, and neural tube development, with expression observed in developing somites, the central nervous system, and skeletal muscle.
The antibody enables detection and localization of DMRT2 in experimental models (e.g., mice, zebrafish) and human tissues through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity is often validated using knockout controls or siRNA-mediated protein knockdown. Research applications include investigating DMRT2's role in embryonic development, tissue regeneration, and disease contexts such as cancer, where dysregulated DMRT2 expression may correlate with tumor progression.
Available as monoclonal or polyclonal versions (commonly raised in rabbits or mice), DMRT2 antibodies are essential for elucidating molecular mechanisms underlying developmental disorders, sexual dimorphism, and cellular differentiation pathways. Proper validation ensures reliability in both qualitative and quantitative analyses, supporting studies in developmental biology, genetics, and clinical research.
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