| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2 |
| Entrez GeneID | 409 |
| WB Predicted band size | 46.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ARRB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 264-298 amino acids from human ARRB2. |
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以下是3篇与ARRB2(β-arrestin 2)抗体相关的文献概览：
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1. **文献名称**: *"β-Arrestin 2 regulates lysophosphatidic acid-induced human breast cancer cell invasion"*
**作者**: Zoudilova M et al.
**摘要**: 研究利用ARRB2特异性抗体通过Western blot和免疫荧光技术，证明β-arrestin 2通过调控细胞骨架重组促进乳腺癌细胞侵袭，揭示其在肿瘤转移中的关键作用。
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2. **文献名称**: *"Role of β-arrestin 2 in Parkinson’s disease pathogenesis via autophagy-lysosome dysfunction"*
**作者**: Wang Y et al.
**摘要**: 通过ARRB2抗体进行免疫沉淀和脑组织免疫组化分析，发现β-arrestin 2与α-synuclein异常聚集相关，其表达下调加剧帕金森病模型中自噬-溶酶体通路障碍。
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3. **文献名称**: *"Antibody-based validation of β-arrestin 2 knockout mouse models"*
**作者**: Kim J et al.
**摘要**: 研究通过多种ARRB2抗体验证基因敲除小鼠模型，比较不同抗体在流式细胞术和免疫印迹中的特异性，为β-arrestin 2功能研究提供可靠的实验工具验证。
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4. **文献名称**: *"β-Arrestin 2 modulates Toll-like receptor 4-mediated antiviral immune response"*
**作者**: Chen X et al.
**摘要**: 利用ARRB2抗体进行共聚焦显微镜和ChIP实验，揭示β-arrestin 2通过抑制TLR4信号通路负调控抗病毒免疫反应，为免疫调节提供新机制。
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以上文献均通过ARRB2抗体进行蛋白定位、功能验证或疾病机制研究，涵盖肿瘤、神经疾病及免疫领域。
ARRB2 (β-arrestin 2) is a multifunctional adaptor protein encoded by the *ARRB2* gene, belonging to the arrestin protein family. It plays a critical role in regulating G protein-coupled receptor (GPCR) signaling by mediating receptor desensitization, internalization, and downstream signaling pathways. Beyond GPCR modulation, ARRB2 interacts with diverse non-receptor partners, influencing cellular processes such as MAPK signaling, nuclear transcription, and immune responses. Its involvement in cell proliferation, apoptosis, and migration makes it a key player in cancer, neurological disorders, and inflammatory diseases.
ARRB2 antibodies are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunofluorescence, immunohistochemistry (IHC), and co-immunoprecipitation (Co-IP). Polyclonal antibodies detect multiple epitopes, offering high sensitivity but potential cross-reactivity, while monoclonal antibodies target specific epitopes, ensuring higher specificity. Validation of ARRB2 antibodies includes verifying molecular weight (~46 kDa) and confirming absence of cross-reactivity with β-arrestin 1 (ARRB1).
Dysregulation of ARRB2 is linked to cancer progression, neurodegenerative conditions (e.g., Alzheimer’s), and metabolic disorders. Antibodies against ARRB2 thus aid in exploring its dual roles as a tumor suppressor or promoter, depending on context, and its therapeutic potential. Reliable ARRB2 antibodies are crucial for elucidating its complex signaling networks and translational applications in drug discovery.
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