Rabbit Polyclonal FAAP24(N-Term) Antibody

The FAAP24 (N-Term) antibody is a crucial tool for studying the FAAP24 protein, a key component of the Fanconi anemia (FA) core complex involved in DNA damage repair. FAAP24 interacts with FANCM to form a heterodimer critical for recognizing and stabilizing stalled replication forks or DNA interstrand crosslinks (ICLs). This complex facilitates the recruitment of downstream FA pathway proteins to orchestrate ICL repair via homologous recombination. The N-Term-specific antibody targets the amino-terminal region of FAAP24. enabling researchers to investigate its expression, localization, and interactions in cellular contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study FAAP24's role in maintaining genomic stability. Dysregulation of FAAP24 is linked to Fanconi anemia, a genetic disorder characterized by bone marrow failure, cancer predisposition, and developmental defects. The antibody also aids in exploring FAAP24's broader functions beyond the FA pathway, including replication stress responses and telomere maintenance. Its specificity for the N-terminal domain ensures precise detection, avoiding cross-reactivity with other FA proteins. This reagent is essential for elucidating molecular mechanisms underlying DNA repair deficiencies and developing therapeutic strategies for FA-related malignancies.