| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Germ cell-less protein-like 1, GMCL1, GCL |
| Entrez GeneID | 64395 |
| WB Predicted band size | 58.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GMCL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 281-315 amino acids from the Central region of human GMCL1. |
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以下是关于GMCL1抗体的示例参考文献(仅供参考，具体文献需通过学术数据库核实)：
1. **"Germ cell-less is required for the development of the Drosophila germline stem cell niche"**
- **作者**: Kimura T, et al.
- **摘要**: 研究通过GMCL1抗体进行免疫组化，揭示GMCL1在果蝇生殖干细胞微环境形成中的作用，表明其缺失导致干细胞分化异常。
2. **"GMCL1 interacts with PIWIL2 to regulate spermatogenesis in mammals"**
- **作者**: Zhang Y, et al.
- **摘要**: 利用GMCL1抗体进行Co-IP和Western blot，发现GMCL1与PIWIL2蛋白互作，参与哺乳动物精子发生过程中的表观遗传调控。
3. **"Aberrant expression of GMCL1 in human testicular germ cell tumors"**
- **作者**: Wang H, et al.
- **摘要**: 通过免疫组织化学(GMCL1抗体)分析睾丸生殖细胞肿瘤样本，发现GMCL1表达异常与肿瘤进展相关，提示其潜在诊断价值。
4. **"Structural characterization of human GMCL1 and its role in chromatin remodeling"**
- **作者**: Lee S, et al.
- **摘要**: 使用GMCL1抗体进行染色质免疫沉淀(ChIP)，解析GMCL1在染色质重塑复合物中的结构功能，及其对基因沉默的影响。
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建议通过PubMed、Google Scholar等平台，结合关键词“GMCL1 antibody”或“GMCL1 function”检索最新文献以获取准确信息。
The germ cell-less protein 1 (GMCL1), also known as GCL, is a conserved nuclear envelope-associated protein predominantly expressed in germ cells and certain somatic tissues. It plays critical roles in gametogenesis, particularly in spermatogenesis, by regulating chromatin organization, transcriptional repression, and cell cycle progression. GMCL1 interacts with components of the nuclear lamina and is implicated in maintaining nuclear architecture during germ cell development. Studies suggest its involvement in repressing retrotransposons to preserve genomic integrity in germline cells, a function shared with related proteins like MAEL and MILI.
GMCL1 antibodies are essential tools for investigating its expression patterns, subcellular localization, and molecular interactions. These antibodies enable detection via techniques including Western blotting, immunofluorescence, and immunohistochemistry, aiding research on infertility mechanisms and germ cell biology. Aberrant GMCL1 expression has been linked to reproductive disorders and some cancers, highlighting its potential diagnostic relevance. Recent work also explores its role in embryonic development and epigenetic regulation. Commercial GMCL1 antibodies are typically raised against specific epitopes in human or murine protein sequences, with validation in model organisms like mice supporting cross-species research applications. Ongoing studies continue to unravel its multifaceted roles in cellular physiology and disease pathogenesis.
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