| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine protease 23, 3421-, Putative secreted protein Zsig13, PRSS23, ZSIG13 |
| Entrez GeneID | 11098 |
| WB Predicted band size | 43.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PRSS23 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 156-191 amino acids from the Central region of human PRSS23. |
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以下是关于PRSS23抗体的参考文献示例(注：以下内容为模拟示例，非真实文献)：
1. **文献名称**：*PRSS23 promotes tumor angiogenesis through protease-activated signaling in breast cancer*
**作者**：Smith A, et al.
**摘要**：本研究利用PRSS23特异性抗体，揭示PRSS23在乳腺癌细胞中高表达，并通过激活基质金属蛋白酶(MMPs)促进血管生成，提示其作为治疗靶点的潜力。
2. **文献名称**：*Role of PRSS23 in ovarian follicle development revealed by antibody-based inhibition*
**作者**：Chen L, et al.
**摘要**：通过PRSS23抗体阻断实验，发现PRSS23在小鼠卵巢卵泡发育过程中调控颗粒细胞凋亡，影响卵母细胞成熟，为生殖障碍研究提供新机制。
3. **文献名称**：*PRSS23 mediates extracellular matrix remodeling in pulmonary fibrosis*
**作者**：Wang Y, et al.
**摘要**：研究使用PRSS23抗体进行组织染色，发现PRSS23在肺纤维化患者组织中异常高表达，并通过降解胶原蛋白促进成纤维细胞活化，加剧纤维化进程。
4. **文献名称**：*PRSS23 as a biomarker for colorectal cancer progression*
**作者**：Kim H, et al.
**摘要**：通过免疫组化(PRSS23抗体)和大样本分析，证实PRSS23在结直肠癌中的表达与转移正相关，可作为预后评估的生物标志物。
(注：如需真实文献，建议通过PubMed或Google Scholar以“PRSS23 antibody”为关键词检索最新研究。)
PRSS23 (Protease, Serine 23) is a member of the trypsin-like serine protease family, characterized by a conserved catalytic triad (His, Asp, Ser) that mediates proteolytic activity. It is implicated in diverse physiological and pathological processes, including extracellular matrix remodeling, cellular signaling, and immune regulation. PRSS23 is expressed in various tissues, with elevated levels observed in certain cancers (e.g., breast, ovarian, and colorectal cancers), where it may promote tumor progression by enhancing invasion, metastasis, or resistance to apoptosis. Its enzymatic activity is thought to regulate key substrates involved in growth factor activation, inflammation, or tissue repair pathways.
PRSS23 antibodies are essential tools for detecting and quantifying PRSS23 expression in research settings. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PRSS23 localization, expression patterns, and regulatory mechanisms in disease models. Commercially available antibodies often target specific epitopes within the catalytic domain or unique regions of the protein to ensure specificity. Validation typically includes testing in knockout cell lines or tissues to confirm minimal cross-reactivity with related serine proteases. Research on PRSS23 has grown due to its potential as a diagnostic biomarker or therapeutic target, particularly in oncology and inflammatory diseases. However, functional studies remain ongoing to fully elucidate its molecular interactions and pathophysiological roles.
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