| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Thiosulfate sulfurtransferase, Rhodanese, TST |
| Entrez GeneID | 7263 |
| WB Predicted band size | 33.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This TST antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 170-203 amino acids from the Central region of human TST. |
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以下是关于结核病(TB)诊断中抗体研究的参考文献，可能与“TST抗体”相关(注：TST通常指结核菌素皮肤试验，但抗体研究多针对结核抗原)：
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1. **文献名称**：*Humoral Immune Responses to Mycobacterium tuberculosis-Specific Antigens in Tuberculosis Patients*
**作者**：Li, L., Qiao, S., Chen, X. 等
**摘要**：研究评估了活动性结核病患者对MTB特异性抗原(如ESAT-6/CFP-10)的抗体反应，发现IgG水平显著升高，提示抗体检测可作为辅助诊断手段，但敏感性低于细胞免疫检测(如IGRA)。
2. **文献名称**：*Evaluation of Antibody Responses to Recombinant Antigens for Diagnosing Latent and Active Tuberculosis*
**作者**：Liu, J., Wang, Y., Zhang, H. 等
**摘要**：通过检测Ag85B和MPT64抗原的抗体水平，发现联合多种抗原可提高活动性结核的诊断特异性，但对潜伏感染(LTBI)的检测效果有限。
3. **文献名称**：*Comparative Analysis of T-Cell and B-Cell Responses in Tuberculosis Infection*
**作者**：Pai, M., O’Brien, R.
**摘要**：综述指出，抗体检测在结核病中的敏感性和特异性普遍低于T细胞免疫方法(如TST和IGRA)，但在免疫抑制患者中可能具有补充价值。
4. **文献名称**：*Serodiagnosis of Tuberculosis Using a Combination of IgA and IgG Antibodies*
**作者**：Steingart, K.R., Flores, L.L., Dendukuri, N. 等
**摘要**：Meta分析表明，基于脂阿拉伯甘露聚糖(LAM)抗原的IgA/IgG联合检测在HIV阳性患者中表现出一定诊断潜力，但总体仍不推荐作为独立检测方法。
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**注**：传统TST检测细胞免疫，上述文献聚焦抗体在结核诊断中的应用。若需针对“TST抗体”的特定研究，建议进一步明确术语定义或补充关键词。
TST antibodies, targeting the tuberculin skin test (TST) antigen, are primarily associated with immune responses to *Mycobacterium tuberculosis* (MTB) infection. The TST, a century-old diagnostic tool, uses purified protein derivative (PPD), a mixture of MTB antigens, to induce a delayed-type hypersensitivity reaction in individuals previously exposed to tuberculosis (TB). However, PPD lacks specificity as it shares antigens with environmental mycobacteria and the BCG vaccine, leading to false-positive results.
Antibodies against TST antigens emerge as part of the humoral immune response, though their role in TB immunity remains less understood compared to cell-mediated responses. Recent research explores their diagnostic potential, particularly in serological assays for TB detection. Unlike TST, which measures cellular immunity, antibody-based tests aim to identify MTB-specific immunoglobulins (e.g., IgG) in blood. However, challenges persist due to variable antibody levels across infection stages (latent vs. active TB) and populations.
Efforts to improve specificity focus on recombinant antigens like ESAT-6. CFP-10. or the 38kDa protein, which are absent in BCG and most non-tuberculous mycobacteria. Despite limitations, TST antibody studies contribute to understanding host-pathogen interactions and refining TB diagnostics, especially in resource-limited settings where rapid, non-sputum-based tests are critical. Ongoing work seeks to harmonize antibody assays with emerging technologies like interferon-gamma release assays (IGRAs) for enhanced accuracy.
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