| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chymotrypsin-like elastase family member 2B, Elastase-2B, CELA2B, ELA2B |
| Entrez GeneID | 51032 |
| WB Predicted band size | 28.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CELA2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 88-122 amino acids from the Central region of human CELA2B. |
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以下是关于CELA2B抗体的3篇参考文献的简要信息(注：CELA2B研究相对较少，部分文献可能侧重功能研究而非抗体开发，以下为模拟示例)：
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1. **标题**: *"Development and validation of a specific polyclonal antibody for human CELA2B in pancreatic tissues"*
**作者**: Zhang L, et al.
**摘要**: 研究报道了一种针对人CELA2B蛋白的多克隆抗体的开发与验证。通过免疫印迹和免疫组化证实该抗体在胰腺组织中的特异性，并发现CELA2B在慢性胰腺炎中的表达显著下调，提示其可能参与疾病病理过程。
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2. **标题**: *"CELA2B as a potential biomarker in colorectal cancer: Insights from antibody-based proteomic analysis"*
**作者**: Tanaka K, et al.
**摘要**: 利用CELA2B特异性抗体进行组织微阵列分析，发现CELA2B在结直肠癌中高表达，且与肿瘤侵袭性相关。研究强调该抗体在癌症诊断中的潜在应用价值。
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3. **标题**: *"Characterization of CELA2B knockout mice using immunohistochemistry and functional assays"*
**作者**: Müller S, et al.
**摘要**: 通过基因编辑技术构建CELA2B敲除小鼠模型，使用商业化CELA2B抗体验证蛋白缺失。研究发现CELA2B缺失导致胰腺酶活性异常，揭示了其在消化酶调控中的关键作用。
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**备注**：CELA2B(Chymotrypsin-like elastase 2B)属于胰蛋白酶家族，相关抗体研究较少，实际文献可能更多聚焦于其酶学功能或疾病关联。建议通过PubMed或Google Scholar以“CELA2B antibody”或“CELA2B immunohistochemistry”为关键词检索最新文献。
The CELA2B antibody targets chymotrypsin-like elastase family member 2B (CELA2B), a serine protease primarily expressed in the pancreas. CELA2B belongs to the elastase family, which plays a role in digesting dietary proteins through cleavage at specific amino acid residues. Unlike other elastases, CELA2B exhibits chymotrypsin-like activity, preferentially hydrolyzing peptide bonds after aromatic residues. It is synthesized as an inactive zymogen (pro-CELA2B) and activated by trypsin-mediated cleavage in the duodenum, aiding in nutrient absorption.
CELA2B antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. Research highlights its potential role in pancreatic disorders, including pancreatitis and pancreatic cancer, where altered protease activity may contribute to disease progression. Antibodies against CELA2B enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, helping to elucidate its tissue-specific expression patterns and regulatory mechanisms. Additionally, these antibodies may aid in exploring CELA2B's interactions with protease inhibitors or its involvement in extracellular matrix remodeling. Recent studies also investigate its diagnostic or therapeutic relevance, particularly in conditions linked to dysregulated proteolytic activity.
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