| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor Dp-2, E2F dimerization partner 2, TFDP2, DP2 |
| Entrez GeneID | 7029 |
| WB Predicted band size | 49.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TFDP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 175-208 amino acids from the Central region of human TFDP2. |
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以下是关于TFDP2抗体的3篇参考文献示例(注：以下内容基于领域内常见研究主题模拟，具体文献请通过学术数据库核实)：
1. **标题**：*TFDP2 regulates hepatocellular carcinoma progression through E2F-mediated cell cycle activation*
**作者**：Chen L, et al.
**摘要**：该研究利用TFDP2抗体检测肝癌组织中TFDP2蛋白表达水平，发现其过表达与细胞周期加速及患者预后不良相关，提示TFDP2通过E2F通路促进肿瘤增殖。
2. **标题**：*The role of TFDP2 in modulating chemoresistance in colorectal cancer*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(使用TFDP2抗体)及基因沉默实验，证明TFDP2高表达与结直肠癌化疗耐药性相关，机制涉及调控DNA损伤修复相关基因转录。
3. **标题**：*Developmental expression pattern of TFDP2 in mouse embryogenesis*
**作者**：Suzuki K, et al.
**摘要**：研究采用TFDP2抗体进行小鼠胚胎组织染色，揭示TFDP2在心脏和神经系统发育中的时空特异性表达，提示其在胚胎分化中的调控作用。
**提示**：实际文献检索建议使用PubMed或Web of Science，以“TFDP2 antibody”及“E2F/DP complex”为关键词，并筛选涉及分子机制或疾病应用的研究。
The TFDP2 (Transcription Factor Dp Family Member 2) antibody is a tool used to detect and study the TFDP2 protein, a key regulator of cell cycle progression and transcription. TFDP2 belongs to the DP family of transcription factors, which form heterodimers with E2F proteins to regulate genes involved in DNA replication, mitosis, and apoptosis. Unlike its homolog TFDP1. TFDP2 exhibits distinct expression patterns and functional roles, particularly in embryonic development and certain cancers. It interacts with E2F4 and E2F5. influencing transcriptional repression and cell cycle exit.
Research using TFDP2 antibodies has highlighted its involvement in tumorigenesis, with studies showing dysregulation in cancers like hepatocellular carcinoma and glioblastoma. The antibody is essential for techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess TFDP2 expression levels, localization, and interactions. Validated antibodies help elucidate post-translational modifications, such as phosphorylation, that modulate its activity.
TFDP2 antibodies are also employed in developmental biology, as TFDP2 knockout models display embryonic lethality and defects in placental development. Their specificity and reliability are critical for distinguishing TFDP2 from TFDP1 in overlapping pathways. Ongoing studies focus on its role in cellular senescence, differentiation, and therapeutic targeting, making TFDP2 antibodies vital for advancing molecular and cancer biology research.
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