Rabbit Polyclonal FMN1 Antibody

The FMN1 antibody is a crucial tool in studying the formin family protein FMN1 (Formin 1), which plays a key role in regulating actin cytoskeleton dynamics. Formins are large, multidomain proteins involved in nucleating and elongating linear actin filaments, essential for processes like cell motility, cytokinesis, and intracellular trafficking. FMN1 specifically contributes to actin assembly in specialized structures such as stress fibers, filopodia, and adherens junctions, impacting cell morphology, adhesion, and signaling. Researchers employ FMN1 antibodies primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect FMN1 expression levels, subcellular localization, and interactions with binding partners. These antibodies are critical for investigating FMN1's involvement in physiological processes (e.g., embryonic development, neuronal growth) and pathological conditions, including cancer metastasis and neurological disorders. Commercially available FMN1 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, with validation through knockout controls or siRNA-mediated knockdown to confirm specificity. Recent studies using FMN1 antibodies have revealed its functional diversity across tissues and its crosstalk with other cytoskeletal regulators like Rho GTPases, highlighting its potential as a therapeutic target in diseases characterized by cytoskeletal dysregulation.