Rabbit Polyclonal PSMB6 Antibody

The proteasome subunit beta type-6 (PSMB6), also known as β1i, is a critical component of the immunoproteasome, a specialized form of the 20S proteasome involved in antigen processing and immune response regulation. PSMB6 replaces the constitutive β1 subunit in immunoproteasomes, enhancing proteolytic activity toward hydrophobic and basic peptide residues. This subunit is induced by interferon-gamma (IFN-γ) and plays a key role in generating antigenic peptides presented by MHC class I molecules, linking proteasome function to adaptive immunity. PSMB6 antibodies are essential tools for studying immunoproteasome dynamics, particularly in autoimmune diseases, cancer, and viral infections where immunoproteasome activity is dysregulated. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and subunit composition. Research using PSMB6 antibodies has revealed its overexpression in certain cancers, suggesting a role in tumor immune evasion, while its inhibition is being explored as a therapeutic strategy. Additionally, these antibodies aid in understanding neurodegenerative disorders associated with proteasome dysfunction. Commercial PSMB6 antibodies are typically monoclonal or polyclonal, raised against specific epitopes, and require validation for cross-reactivity due to high homology among proteasome subunits.