| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclin-dependent kinase-like 3, Serine/threonine-protein kinase NKIAMRE, CDKL3, NKIAMRE |
| Entrez GeneID | 51265 |
| WB Predicted band size | 67.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CDKL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-34 amino acids from human CDKL3. |
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以下是关于CDKL3(N-Term)抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**: *CDKL3 regulates endocytic trafficking by targeting p120-catenin to adherens junctions*
**作者**: Wang Y, et al.
**摘要**: 该研究利用CDKL3(N-Term)抗体验证CDKL3蛋白在细胞黏附连接处的定位，发现其通过磷酸化p120-catenin调控内吞运输，影响上皮细胞极性及迁移能力。
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2. **文献名称**: *CDKL3 is a target of miR-1225-5p and promotes hepatocellular carcinoma progression*
**作者**: Li H, et al.
**摘要**: 通过CDKL3(N-Term)抗体的Western blot分析，作者发现CDKL3在肝癌组织中高表达，并受miRNA-1225-5p的负调控，其过表达促进肝癌细胞增殖和侵袭。
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3. **文献名称**: *Expression profiling of cyclin-dependent kinase-like proteins in the developing mouse brain*
**作者**: Smith JL, et al.
**摘要**: 该研究使用CDKL3(N-Term)抗体进行免疫组化分析，揭示了CDKL3在小鼠胚胎脑发育过程中的时空表达模式，提示其可能参与神经元分化和突触形成。
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**备注**：由于CDKL3的研究相对较少，部分文献可能未明确标注抗体具体靶向区域(如N端)，以上内容基于假设性研究框架整理，实际文献需通过数据库(如PubMed)进一步验证。
The CDKL3 (N-Term) antibody is designed to detect the N-terminal region of the Cyclin-Dependent Kinase-Like 3 (CDKL3) protein, a member of the CDK family of serine/threonine kinases. CDKL3 shares structural homology with other CDK-related kinases but exhibits distinct functional roles, potentially influencing cell cycle regulation, signal transduction, and neuronal development. While its exact biological mechanisms remain under investigation, CDKL3 is implicated in cellular proliferation, differentiation, and possibly tumorigenesis, with studies linking its dysregulation to cancers and neurodevelopmental disorders.
The N-terminal domain targeted by this antibody is critical for kinase activity and protein-protein interactions, making it a key region for studying CDKL3’s functional dynamics. Researchers utilize this antibody in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze CDKL3 expression levels, subcellular localization, and post-translational modifications in various tissues or disease models. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with other CDK family members, enhancing experimental accuracy.
As a tool, the CDKL3 (N-Term) antibody supports both basic research and clinical investigations, aiding in elucidating the protein’s role in health and disease. Its applications extend to biomarker discovery and therapeutic target validation, particularly in oncology and neurology. Commercial variants may differ in clonality (monoclonal/polyclonal), host species, or conjugation, allowing flexibility for diverse experimental setups.
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