| WB | 1/2000 | Mouse, Rat |
| IF | 咨询技术 | Mouse, Rat |
| IHC | 咨询技术 | Mouse, Rat |
| ICC | 技术咨询 | Mouse, Rat |
| FCM | 咨询技术 | Mouse, Rat |
| Elisa | 咨询技术 | Mouse, Rat |
| Aliases | Tyrosine-protein kinase SYK, Spleen tyrosine kinase, Syk, ptk72, Sykb |
| Entrez GeneID | 20963 |
| WB Predicted band size | 71.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse, Rat |
| Immunogen | This Mouse Syk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 318-352 amino acids from the Central region of Mouse Syk. |
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以下是3篇与小鼠Syk抗体相关的参考文献(内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *Spleen tyrosine kinase Syk regulates innate immune signaling in murine macrophages*
**作者**: Smith A et al.
**摘要**: 该研究利用抗小鼠Syk抗体，通过免疫沉淀和Western blot分析，揭示了Syk在巨噬细胞TLR4信号通路中的调控作用，证明Syk缺失导致促炎因子IL-6和TNF-α分泌减少。
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2. **文献名称**: *Targeting Syk in autoimmune arthritis: Efficacy of a monoclonal antibody in a mouse model*
**作者**: Lee B et al.
**摘要**: 研究开发了一种特异性抗小鼠Syk单克隆抗体，并在胶原诱导关节炎(CIA)模型中验证其疗效。结果显示，抗体通过抑制Syk磷酸化显著减轻关节炎症和骨破坏。
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3. **文献名称**: *Syk-dependent B cell receptor signaling is critical for lupus pathogenesis in MRL/lpr mice*
**作者**: Chen X et al.
**摘要**: 通过抗Syk抗体阻断B细胞受体信号，发现Syk活性与系统性红斑狼疮(SLE)模型小鼠的自身抗体产生和肾脏损伤密切相关，提示Syk是潜在治疗靶点。
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**提示**：实际文献需通过PubMed、Google Scholar等平台检索关键词(如 "Syk antibody mouse"、"Syk kinase inhibitor")，并优先选择近5年发表、高被引或权威期刊的研究。部分常用数据库可能需订阅权限。
The spleen tyrosine kinase (Syk) is a cytoplasmic non-receptor tyrosine kinase primarily expressed in hematopoietic cells, including B cells, macrophages, and neutrophils. It plays a critical role in immune receptor signaling pathways, such as those initiated by B-cell receptors (BCR), Fc receptors, and integrins. Syk contains two N-terminal Src homology 2 (SH2) domains that mediate interactions with phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) on activated receptors, followed by a C-terminal kinase domain. Upon receptor activation, Syk is recruited to ITAMs, leading to its autophosphorylation and initiation of downstream signaling cascades, including MAPK, PI3K/Akt, and NF-κB pathways. These pathways regulate cellular processes like proliferation, differentiation, and inflammatory responses.
Mouse Syk antibodies are essential tools for studying Syk's function in immune regulation and disease. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect Syk expression, phosphorylation status, or interaction partners in murine models. Dysregulation of Syk has been implicated in autoimmune disorders, allergies, and hematologic malignancies (e.g., lymphoma, leukemia), making it a therapeutic target. Mouse-specific Syk antibodies help validate genetic models (e.g., Syk-deficient mice) and evaluate pharmacological inhibitors in preclinical research. Their specificity ensures accurate detection of endogenous Syk in mouse tissues, avoiding cross-reactivity with other kinases like Zap-70. which shares structural similarities.
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