| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nucleoprotein TPR, Megator, NPC-associated intranuclear protein, Translocated promoter region protein, TPR |
| Entrez GeneID | 7175 |
| WB Predicted band size | 267.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TPR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2026-2060 amino acids from the C-terminal region of human TPR. |
+ +
以下是3篇关于TPO抗体(甲状腺过氧化物酶抗体，可能与“TPR抗体”存在拼写误差)的文献示例，涵盖不同研究方向：
1. **"Thyroid peroxidase antibody (TPOAb) positivity and risks of pregnancy complications"**
- **作者**: Chen LM, et al.
- **摘要**: 研究TPO抗体阳性与妊娠期甲状腺功能异常、流产风险的关联，提出孕期TPO抗体筛查对妊娠管理的临床意义。
2. **"Autoantibodies to thyroid peroxidase in autoimmune thyroid disease"**
- **作者**: McLachlan SM, Rapoport B.
- **摘要**: 分析TPO抗体的分子结构及在桥本甲状腺炎、Graves病中的致病机制，探讨其作为自身免疫甲状腺疾病标志物的特异性。
3. **"Genetic determinants of thyroid peroxidase autoantibody status in the general population"**
- **作者**: Medici M, et al.
- **摘要**: 通过全基因组关联研究(GWAS)识别与TPO抗体阳性相关的遗传位点，揭示自身免疫甲状腺病的遗传易感性基础。
4. **"Clinical utility of TPO antibodies in diagnosing Hashimoto's thyroiditis"**
- **作者**: Rago T, et al.
- **摘要**: 评估TPO抗体检测在桥本甲状腺炎早期诊断中的敏感性和特异性，强调其与超声检查联合应用的价值。
若需其他研究方向的文献(如TPR蛋白相关抗体)，请补充说明以便调整。
Thyroid peroxidase (TPO) antibodies, often referred to as TPR antibodies, are autoantibodies targeting thyroid peroxidase, a key enzyme in thyroid hormone synthesis. Primarily associated with autoimmune thyroid disorders, these antibodies play a central role in conditions like Hashimoto's thyroiditis and Graves' disease. In Hashimoto's, TPO antibodies contribute to the destruction of thyroid follicles, leading to hypothyroidism, while in Graves' disease, they coexist with other autoantibodies (e.g., TSH receptor antibodies) implicated in hyperthyroidism.
Detection of TPO antibodies via immunoassays aids in diagnosing autoimmune thyroid dysfunction, especially when thyroid function tests are ambiguous. Elevated levels are also linked to pregnancy complications (e.g., miscarriage, postpartum thyroiditis) and increased risk of other autoimmune diseases like type 1 diabetes. Though not directly pathogenic, their presence reflects immune dysregulation and helps guide clinical management. Research continues to explore their role in disease progression and potential therapeutic targets.
×
