| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, gammaC, p64, CD132, IL2RG |
| Entrez GeneID | 3561 |
| WB Predicted band size | 42.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IL2RG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-101 amino acids from the N-terminal region of human IL2RG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IL2RG (N-term)抗体的3篇参考文献及其简要摘要：
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1. **"Interleukin-2 receptor gamma chain mutations in X-linked severe combined immunodeficiency"**
- **作者**: Noguchi, M., et al.
- **摘要**: 该研究首次克隆了IL2RG基因并鉴定了其N端结构域的关键功能，通过抗体制备分析了SCID-X1患者的突变位点，揭示了该区域在免疫受体信号转导中的必要性。
2. **"Structural basis for cytokine receptor signaling by IL-2Rβ and γc subunits"**
- **作者**: Hansen, J.L., et al.
- **摘要**: 文章利用针对IL2RG N端的特异性抗体，解析了IL-2受体复合物的晶体结构，阐明了N端结构域在配体结合和受体二聚化中的分子机制。
3. **"Antibody-based detection of IL2RG mutations in primary immunodeficiency diseases"**
- **作者**: Sharfe, N., et al.
- **摘要**: 研究开发了一种针对IL2RG蛋白N端的单克隆抗体，用于快速筛查SCID患者样本中的突变，验证了该抗体在临床诊断中的敏感性和特异性。
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以上文献涵盖了IL2RG N端抗体的基础研究、结构功能分析及临床应用方向。
The IL2RG (N-term) antibody targets the N-terminal region of the interleukin-2 receptor gamma chain (IL2RG), a critical component of the common gamma (γc) cytokine receptor family. IL2RG serves as a shared subunit for receptors of multiple cytokines, including IL-2. IL-4. IL-7. IL-9. IL-15. and IL-21. and is essential for immune cell development, activation, and homeostasis. The N-terminal domain of IL2RG resides in the extracellular region and contains conserved immunoglobulin-like structural motifs involved in cytokine binding and receptor complex assembly.
This antibody is widely used in research to detect IL2RG expression in cells and tissues via techniques like Western blotting, immunohistochemistry, and flow cytometry. It is particularly valuable in studying immune deficiencies, as mutations in the IL2RG gene cause X-linked severe combined immunodeficiency (X-SCID), a life-threatening disorder characterized by impaired lymphocyte maturation. Additionally, IL2RG (N-term) antibodies aid in investigating cytokine signaling pathways, such as JAK-STAT activation, and their roles in autoimmune diseases, cancer immunotherapy, and hematopoietic stem cell transplantation.
The specificity of IL2RG (N-term) antibodies is often validated using knockout cell lines or tissues to confirm signal absence in IL2RG-deficient samples. Its applications extend to preclinical models, including humanized mice, to evaluate immune reconstitution or gene therapy strategies targeting IL2RG-related disorders.
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