| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein L-Myc, Class E basic helix-loop-helix protein 38, bHLHe38, Protein L-Myc-1, V-myc myelocytomatosis viral oncogene homolog, MYCL, BHLHE38, LMYC, MYCL1 |
| Entrez GeneID | 4610 |
| WB Predicted band size | 40.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MYCL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 271-303 amino acids from human MYCL1. |
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以下是3篇关于MYCL1抗体的参考文献及其摘要概括：
1. **文献名称**: *"MYCL1 amplification and expression in small cell lung cancer"*
**作者**: Kim YH et al.
**摘要**: 该研究利用MYCL1特异性抗体(克隆号：EPR20018)通过免疫组化分析小细胞肺癌组织，发现MYCL1基因扩增与蛋白高表达显著相关，提示其可能作为该癌症亚型的潜在生物标志物。
2. **文献名称**: *"Functional characterization of MYCL1 in cellular proliferation using CRISPR and antibody-based assays"*
**作者**: Zhang L et al.
**摘要**: 研究通过Western blot(抗MYCL1抗体：Abcam ab12345)和免疫荧光技术验证MYCL1在肺癌细胞系中的表达，发现敲低MYCL1可抑制细胞增殖，表明其在肿瘤生长中的调控作用。
3. **文献名称**: *"Antibody validation for MYCL1 in paraffin-embedded tissues"*
**作者**: Patel RK et al.
**摘要**: 系统验证了多种MYCL1抗体(包括克隆号D3H7和EPR20018)在福尔马林固定组织的免疫组化应用，确认EPR20018抗体在检测肺癌和神经母细胞瘤中具有高特异性和灵敏度。
4. **文献名称**: *"MYCL1 interacts with the NuRD complex to drive oncogenic programs"*
**作者**: Gomez CB et al.
**摘要**: 通过免疫共沉淀(使用Santa Cruz Biotechnology的MYCL1抗体sc-123)发现MYCL1与染色质重塑复合体NuRD相互作用，揭示其通过表观遗传调控促进肿瘤进展的机制。
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注：以上文献为示例性质，实际引用时需根据具体研究补充完整信息(期刊、年份、DOI等)。建议通过PubMed或Google Scholar以“MYCL1 antibody” + “应用场景(如Western blot/IHC)”为关键词检索最新文献。
The MYCL1 antibody is a crucial tool in molecular and cancer research, targeting the MYCL1 protein encoded by the MYCL1 gene (also known as L-MYC). MYCL1 belongs to the MYC family of transcription factors, which includes c-MYC and N-MYC, and plays a role in regulating cell proliferation, differentiation, and apoptosis. Unlike its oncogenic counterparts c-MYC and N-MYC, MYCL1's functional role remains less defined, though it has been implicated in certain cancers, particularly small-cell lung cancer (SCLC) and neuroblastoma. Amplification or dysregulation of MYCL1 is associated with tumor progression and poor prognosis.
MYCL1 antibodies are widely used in research to detect and quantify MYCL1 expression in cells and tissues via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate MYCL1's expression patterns, interactions, and regulatory mechanisms in both normal and pathological states. Commercial MYCL1 antibodies are typically developed using immunogenic peptides or recombinant protein fragments, validated for specificity and sensitivity.
Studies utilizing MYCL1 antibodies have contributed to understanding its potential as a biomarker or therapeutic target, though clinical applications remain exploratory. Researchers also investigate its role in MYC family redundancy and context-dependent oncogenic behavior. Reliable MYCL1 antibodies are essential for advancing insights into its biological and pathological significance.
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