Rabbit Polyclonal SEMA4G Antibody

中文名： SEMA4G抗体
别名： Semaphorin-4G, SEMA4G, KIAA1619

货号: IPDX33203

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	1/2000	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	Semaphorin-4G, SEMA4G, KIAA1619
Entrez GeneID	57715
WB Predicted band size	91.5kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This SEMA4G antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 360-393 amino acids from the Central region of human SEMA4G.

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All lanes : Anti-SEMA4G Antibody (Center) at 1:2000 dilution Lane 1: A549 whole cell lysates Lane 2: Hela whole cell lysates Lane 3: HT-29 whole cell lysates Lane 4: SH-SY5Y whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 91 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

参考文献

以下是关于 **SEMA4G抗体** 的模拟参考文献(基于领域相关主题，非真实文献)：

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1. **文献名称**：*SEMA4G Antibody Blocks Viral Entry by Targeting Host-Pathogen Interactions*

**作者**：Chen Y. et al.

**摘要**：研究利用SEMA4G特异性抗体抑制病毒(如丙型肝炎病毒)进入宿主细胞的机制，发现抗体通过阻断SEMA4G与病毒蛋白的结合，显著降低病毒感染效率。

2. **文献名称**：*SEMA4G as a Tumor Biomarker: Validation of a Novel Monoclonal Antibody for Immunohistochemistry*

**作者**：Wang L. et al.

**摘要**：开发了一种高特异性抗SEMA4G的单克隆抗体，用于检测多种癌症组织(如肺癌、结直肠癌)中SEMA4G的异常表达，证实其作为肿瘤预后标志物的潜力。

3. **文献名称**：*SEMA4G Antibody Attenuates Autoimmune Inflammation by Modulating T-cell Signaling*

**作者**：Kumar R. et al.

**摘要**：在小鼠模型中，抗SEMA4G抗体通过干扰T细胞受体信号通路，抑制促炎细胞因子释放，缓解实验性自身免疫性脑脊髓炎(EAE)症状。

4. **文献名称**：*Structural Characterization of SEMA4G Epitopes for Therapeutic Antibody Development*

**作者**：Saito M. et al.

**摘要**：解析了SEMA4G蛋白的关键抗原表位，并基于此设计了一种人源化抗体，体外实验显示其可有效抑制SEMA4G介导的血管生成信号通路。

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**注**：以上内容为示例性模拟，实际文献需通过数据库(如PubMed、Web of Science)检索确认。

背景信息

The SEMA4G antibody is designed to target SEMA4G (Semaphorin-4G), a member of the semaphorin protein family, which plays critical roles in cellular signaling, axon guidance, and immune regulation. Semaphorins are characterized by a conserved "sema" domain and function as ligands or receptors in pathways influencing cell migration, angiogenesis, and neural development. SEMA4G, a transmembrane protein, is involved in cell-cell communication and interacts with receptors such as plexins or neuropilins to mediate downstream signaling. Its expression is observed in various tissues, including the nervous and immune systems, suggesting roles in neurodevelopment and immune modulation.

Research on SEMA4G has linked it to pathological conditions such as cancer, neurodegenerative disorders, and autoimmune diseases. In cancer, SEMA4G may regulate tumor angiogenesis, metastasis, and immune evasion, making it a potential therapeutic target or biomarker. Antibodies against SEMA4G are primarily used in research to detect its expression via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding in understanding its biological functions and mechanisms. Additionally, SEMA4G antibodies may have therapeutic applications, such as blocking aberrant signaling in disease states. Despite its emerging significance, the full scope of SEMA4G's interactions and pathways remains under investigation, highlighting the need for further studies to unravel its clinical potential.