| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proteolipid protein 2, Differentiation-dependent protein A4, Intestinal membrane A4 protein, PLP2, A4 |
| Entrez GeneID | 5355 |
| WB Predicted band size | 16.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PLP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-166 amino acids from the C-terminal region of human PLP2. |
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以下是关于PLP2抗体的模拟参考文献示例(基于研究领域常见主题生成，非真实文献)：
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1. **文献名称**：《PLP2抗体在胶质瘤诊断中的特异性与临床应用》
**作者**：Smith J. et al.
**摘要**：本研究验证了PLP2抗体对胶质瘤细胞中过表达的Proteolipid Protein 2(PLP2)的特异性识别能力，发现其可作为神经胶质瘤的潜在生物标志物，并探讨了其在组织切片免疫组化诊断中的应用价值。
2. **文献名称**：《PLP2通过调控自噬促进乳腺癌细胞存活的作用机制》
**作者**：Zhang L. et al.
**摘要**：通过PLP2抗体介导的蛋白敲低实验，揭示了PLP2在乳腺癌细胞中通过激活自噬通路抑制凋亡的分子机制，提示PLP2可能成为乳腺癌治疗的靶点。
3. **文献名称**：《PLP2抗体在小鼠髓鞘再生模型中的功能研究》
**作者**：Garcia R. et al.
**摘要**：利用PLP2抗体阻断实验，证明PLP2在髓鞘损伤修复过程中参与少突胶质细胞分化，为多发性硬化症等脱髓鞘疾病的治疗提供新思路。
4. **文献名称**：《PLP2的亚细胞定位及其与内质网应激的关联》
**作者**：Wang Y. et al.
**摘要**：通过PLP2抗体的免疫荧光染色，发现PLP2在内质网应激条件下的表达上调及定位变化，提示其可能在细胞应激响应中发挥调控作用。
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注：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
The PLP2 (Proteolipid Protein 2) antibody targets the PLP2 protein, a member of the tetraspanin superfamily characterized by four transmembrane domains. PLP2. also known as TSPAN2. is ubiquitously expressed and localizes to the endoplasmic reticulum (ER) and plasma membrane. It plays roles in membrane organization, intracellular trafficking, and cell signaling. PLP2 has been implicated in regulating ER stress responses, potentially influencing cell survival under stress conditions.
In research, PLP2 antibodies are essential tools for detecting PLP2 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate PLP2's involvement in pathological processes, including cancer, where PLP2 overexpression has been observed in certain tumors, suggesting a role in tumorigenesis or metastasis. Additionally, PLP2's interaction with viral proteins, such as those from hepatitis C virus, highlights its relevance in host-pathogen interactions.
Studies also explore PLP2's connection to neurological disorders, though its exact mechanisms remain less defined compared to its homolog PLP1. a key myelin component. The PLP2 antibody thus serves as a critical reagent for advancing understanding of cellular stress pathways, cancer biology, and viral infection mechanisms, bridging molecular insights to potential therapeutic applications.
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