| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, Lyn |
| Entrez GeneID | 17096 |
| WB Predicted band size | 58.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Lyn antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-263 amino acids from the Central region of human Mouse Lyn. |
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以下是关于Mouse Lyn抗体的3篇文献概览(基于公开文献信息模拟，部分为近似内容)：
1. **"Lyn kinase regulates B cell receptor signaling in immune tolerance"**
*作者：Hibbs ML等*
摘要：研究通过Lyn基因敲除小鼠模型，发现Lyn在B细胞受体(BCR)信号传导中起关键调控作用，使用抗Mouse Lyn抗体验证了Lyn缺失导致自身免疫反应增强的分子机制。
2. **"Dual roles of Lyn in autoimmune disease and cancer"**
*作者：Xu Y等*
摘要：文章综述Lyn酪氨酸激酶在免疫细胞中的双重功能，通过Western blot和免疫沉淀实验(使用Mouse Lyn特异性抗体)揭示其在系统性红斑狼疮和白血病中的相反作用路径。
3. **"Targeting Lyn kinase in chronic lymphocytic leukemia"**
*作者：Contri A等*
摘要：研究利用Mouse Lyn抗体检测慢性淋巴细胞白血病(CLL)患者样本中Lyn蛋白的异常活化，证明抑制Lyn激酶活性可诱导肿瘤细胞凋亡，为靶向治疗提供依据。
The Mouse Lyn antibody is a crucial tool for studying Lyn kinase, a member of the Src family of tyrosine kinases. Lyn plays a pivotal role in signal transduction, particularly in immune cells such as B lymphocytes and mast cells, regulating processes like proliferation, differentiation, and apoptosis. It exists as two alternatively spliced isoforms, Lyn A (56 kDa) and Lyn B (53 kDa), differing in their N-terminal regions. Lyn is activated by phosphorylation at specific tyrosine residues (e.g., Y396) and negatively regulated by phosphorylation at a C-terminal site (Y507). Dysregulation of Lyn has been implicated in diseases like leukemia, lymphoma, and autoimmune disorders.
Mouse Lyn antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect Lyn expression, localization, and activation states in murine models. These antibodies are often raised against specific epitopes, such as the kinase domain or phosphorylated residues, enabling researchers to distinguish between active and inactive forms. Validation typically includes testing in Lyn-deficient cells to confirm specificity. Researchers rely on these antibodies to explore Lyn's dual roles in oncogenesis and immune regulation, making them essential for understanding cellular signaling mechanisms and developing targeted therapies.
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