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Rabbit Polyclonal HNRNPA1 Antibody

  • 中文名： HNRNPA1抗体
  • 别    名： Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
货号: IPDX33139
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHeterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
Entrez GeneID3178
WB Predicted band size38.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human HNRNPA1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于HNRNPA1抗体的3篇参考文献的简要总结：

1. **文献名称**: *"HnRNP proteins and the biogenesis of mRNA"*

**作者**: Dreyfuss, G. et al.

**摘要**: 该研究系统综述了hnRNP蛋白(包括HNRNPA1)在mRNA生成和加工中的作用，重点关注其参与RNA剪接、运输及稳定性调控的分子机制，并讨论了相关抗体的应用场景。

2. **文献名称**: *"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS"*

**作者**: Kim, H.J. et al.

**摘要**: 研究发现HNRNPA1基因突变通过促进病理蛋白聚集导致肌萎缩侧索硬化症(ALS)和多系统蛋白病，文中使用特异性抗体验证了突变蛋白在细胞模型中的异常聚集行为。

3. **文献名称**: *"TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia"*

**作者**: Mackenzie, I.R. & Neumann, M.

**摘要**: 该综述分析了HNRNPA1与TDP-43/FUS等RNA结合蛋白在神经退行性疾病中的关联，强调其抗体在检测脑组织病理包涵体及疾病生物标志物开发中的关键作用。

注：以上文献为示例性质，具体引用时请核对实际发表年份及期刊信息。

背景信息

The HNRNPA1 antibody is a crucial tool in studying the heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), a multifunctional RNA-binding protein involved in mRNA processing, splicing, and transport. HNRNPA1 regulates gene expression by interacting with pre-mRNA and influencing splicing decisions, stability, and localization. It plays roles in telomere maintenance, DNA repair, and stress granule formation. Research using HNRNPA1 antibodies has linked the protein to neurodegenerative diseases (e.g., amyotrophic lateral sclerosis, frontotemporal dementia) and cancer, where its dysregulation affects alternative splicing and oncogene expression. Mutations in HNRNPA1 are associated with multisystem proteinopathy due to its propensity to form pathological aggregates. Antibodies against HNRNPA1 enable detection via Western blot, immunohistochemistry, and immunofluorescence, helping elucidate its cellular distribution and disease mechanisms. They also aid in studying HNRNPA1's interaction with partners like TDP-43 and its role in stress responses. Validated antibodies are essential for distinguishing HNRNPA1 from homologous family members (e.g., HNRNPA2B1) and investigating post-translational modifications impacting its function.

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