| WB | 1/2000 | Human,Mouse,zebrafish, |
| IF | 咨询技术 | Human,Mouse,zebrafish, |
| IHC | 咨询技术 | Human,Mouse,zebrafish, |
| ICC | 技术咨询 | Human,Mouse,zebrafish, |
| FCM | 咨询技术 | Human,Mouse,zebrafish, |
| Elisa | 咨询技术 | Human,Mouse,zebrafish, |
| Aliases | Cytoplasmic FMR1-interacting protein 1 homolog, cyfip1 {ECO:0000312|ZFIN:ZDB-GENE-030131-8557} |
| Entrez GeneID | 336613 |
| WB Predicted band size | 145.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,zebrafish, |
| Immunogen | This DANRE cyfip1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 524-558 amino acids from the Central region of DANRE cyfip1. |
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以下是假设性的示例文献，供参考(实际文献需通过学术数据库验证)：
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1. **文献名称**: "Cyfip1 regulates neuronal migration in zebrafish through the WAVE complex"
**作者**: Smith J, et al.
**摘要**: 研究利用斑马鱼模型发现Cyfip1通过调控WAVE复合体影响神经元迁移。使用抗Cyfip1抗体进行免疫组化，证实其在发育脑区的表达模式，并揭示其缺失导致轴突导向异常。
2. **文献名称**: "Interactions between FMRP and Cyfip1 in zebrafish synaptic plasticity"
**作者**: Lee H, et al.
**摘要**: 探讨斑马鱼中FMRP与Cyfip1的相互作用对突触可塑性的影响。通过Western blot和免疫共沉淀(使用Cyfip1抗体)证明两者在神经发育中的功能协同性，并关联脆性X综合征表型。
3. **文献名称**: "Behavioral profiling of cyfip1 knockout zebrafish reveals autism-related phenotypes"
**作者**: Garcia R, et al.
**摘要**: 构建斑马鱼cyfip1敲除模型，利用Cyfip1抗体验证蛋白表达缺失，发现社交行为缺陷和重复动作增多，提示其作为自闭症研究的潜在模型。
4. **文献名称**: "Tissue-specific expression of cyfip1 during zebrafish embryogenesis"
**作者**: Chen L, et al.
**摘要**: 通过整胚免疫染色(Cyfip1抗体)系统描述斑马鱼胚胎期Cyfip1的时空表达图谱，显示其在神经系统和肌肉发育中的动态分布。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“zebrafish cyfip1 antibody”或“Danio rerio cyfip1”检索确认。部分研究可能侧重基因功能而非抗体应用，建议结合具体需求筛选。
The DANRE (Danio rerio) Cyfip1 antibody is a tool used to study the cytoplasmic FMR1-interacting protein 1 (Cyfip1) in zebrafish models. Cyfip1 is a conserved protein involved in neuronal development, synaptic plasticity, and mRNA translation regulation. It interacts with Fragile X Mental Retardation Protein (FMRP) to regulate the transport and local translation of target mRNAs, critical for proper neural circuit formation. Cyfip1 also functions within the WAVE regulatory complex (WRC), linking actin cytoskeleton remodeling to cellular processes like cell migration and dendritic spine morphogenesis. Dysregulation of Cyfip1 is associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia, as well as Fragile X syndrome (FXS).
In zebrafish research, the DANRE Cyfip1 antibody enables detection and localization of Cyfip1 during embryonic development and in adult tissues, facilitating studies on its role in brain development, behavior, and disease mechanisms. Zebrafish, with their genetic tractability and transparent embryos, offer a robust model for visualizing Cyfip1 dynamics in vivo. This antibody is typically validated via Western blotting, immunohistochemistry, or immunofluorescence to ensure specificity for zebrafish Cyfip1. aiding investigations into conserved molecular pathways and potential therapeutic targets for neurodevelopmental disorders.
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