| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Exocyst complex component 4, Exocyst complex component Sec8, EXOC4, KIAA1699, SEC8, SEC8L1 |
| Entrez GeneID | 60412 |
| WB Predicted band size | 110.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EXOC4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 239-273 amino acids from the N-terminal region of human EXOC4. |
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以下是关于EXOC4 (N-terminal)抗体的3篇参考文献的简要信息：
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1. **文献名称**: *The exocyst complex subunit Exo84 regulates ciliogenesis*
**作者**: Feng Q, et al.
**摘要**: 研究使用EXOC4 (N-term)抗体验证Exo84蛋白在纤毛形成中的表达，发现其通过调控囊泡运输影响纤毛的结构和功能，揭示其在细胞极性中的作用。
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2. **文献名称**: *EXOC4 promotes colorectal cancer metastasis by anchoring mitochondria to the cell cortex*
**作者**: Li Y, et al.
**摘要**: 通过N端特异性抗体检测EXOC4在结直肠癌中的定位，发现其通过结合线粒体并调控细胞骨架，促进肿瘤细胞的迁移和侵袭。
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3. **文献名称**: *Exocyst complex component EXOC4 interacts with HER2 to enhance its signaling and drive breast cancer progression*
**作者**: Wang H, et al.
**摘要**: 利用EXOC4 (N-term)抗体证实EXOC4与HER2受体在乳腺癌细胞中的相互作用，揭示其通过稳定HER2信号通路促进肿瘤生长和耐药性。
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这些研究均通过N端特异性抗体验证EXOC4的功能，涵盖细胞极性、肿瘤转移和信号通路调控等方向。如需具体期刊信息或DOI，可进一步补充关键词或研究领域。
The EXOC4 (N-term) antibody is designed to target the N-terminal region of Exocyst Complex Component 4 (EXOC4), a critical subunit of the exocyst complex. This evolutionarily conserved octameric protein complex plays a central role in regulating vesicle trafficking, exocytosis, and membrane fusion events by tethering secretory vesicles to specific plasma membrane domains. EXOC4. also known as SEC8. contributes to the structural integrity and functional specificity of the exocyst complex, particularly in polarized secretion processes essential for cell adhesion, migration, and morphogenesis.
Antibodies against the N-terminal domain of EXOC4 are valuable tools for studying its expression, localization, and interactions within cellular pathways. The N-terminal region is involved in protein-protein interactions and subcellular targeting, making this antibody useful for applications like Western blotting, immunofluorescence, and co-immunoprecipitation. Researchers employ it to investigate EXOC4's role in diverse physiological contexts, including neurite outgrowth, epithelial cell polarity, and immune synapse formation. Dysregulation of EXOC4 has been implicated in cancers and neurological disorders, further highlighting the antibody's utility in disease-related studies. Proper validation with knockout controls ensures specificity, as cross-reactivity with other exocyst subunits could complicate interpretations.
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