首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal Npy2r(N-term).ctrl Antibody

  • 中文名: Npy2r (N-term).ctrl抗体
  • 别    名: Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, Npy2r
货号: IPDX33119
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNeuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, Npy2r
Entrez GeneID18167
WB Predicted band size42.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Npy2r antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 23-59 amino acids from the N-terminal region of human Npy2r.

+ +

参考文献

以下是基于Npy2r(NPY Y2受体)N端抗体的应用及功能研究的模拟参考文献示例(注:文献为虚构示例,实际需通过学术数据库验证):

---

1. **文献名称**: "Neuropeptide Y Y2 Receptor Localization in Hypothalamic Neurons Regulating Energy Balance"

**作者**: Smith A, et al.

**摘要**: 本研究利用Npy2r (N-term).ctrl抗体通过免疫组化技术,揭示了NPY Y2受体在小鼠下丘脑神经元中的特异性表达,证实其在调节摄食行为和能量代谢中的关键作用,抗体特异性通过敲除模型验证。

---

2. **文献名称**: "Role of NPY Y2 Receptor in Anxiety-Related Behaviors: Insights from Immunoblotting and Knockout Models"

**作者**: Johnson B, et al.

**摘要**: 通过Western blot和免疫荧光技术,结合Npy2r N端抗体,研究发现NPY Y2受体在前额叶皮质中高表达,其表达水平与焦虑行为相关,抗体特异性通过siRNA沉默实验确认。

---

3. **文献名称**: "Validation of a Novel N-terminal Antibody for NPY Y2 Receptor in Gastrointestinal Function Studies"

**作者**: Lee C, et al.

**摘要**: 本文报道了一种针对NPY Y2受体N端的新型抗体验证,该抗体成功用于结肠组织的免疫染色及蛋白质印迹,揭示了受体在肠道运动调控中的功能,并通过肽段阻断实验证实抗体特异性。

---

4. **文献名称**: "NPY Y2 Receptor Dynamics in Synaptic Plasticity: A Focus on Hippocampal Neurons"

**作者**: Müller D, et al.

**摘要**: 研究使用Npy2r (N-term).ctrl抗体结合共聚焦显微镜技术,发现NPY Y2受体在海马神经元突触中的动态分布,提示其可能参与学习记忆相关的突触可塑性调节。

---

**注意事项**:

- 上述文献为示例,实际文献需通过PubMed、Web of Science等平台检索(关键词:NPY2R antibody、Y2 receptor localization)。

- 推荐查阅抗体供应商(如Abcam、Sigma-Aldrich)的产品说明书,部分会提供引用文献。

- 若研究涉及实验对照设计,建议关注方法学论文或抗体特异性验证相关研究。

背景信息

The Npy2r (N-term).ctrl antibody is a control reagent designed for specificity validation in studies targeting the neuropeptide Y receptor Y2 (NPY2R), a G protein-coupled receptor involved in various physiological processes, including appetite regulation, anxiety, and memory. NPY2R is activated by neuropeptide Y (NPY) and peptide YY (PYY), primarily functioning as a presynaptic autoreceptor to inhibit neurotransmitter release in the central nervous system. The antibody is raised against the N-terminal extracellular domain of NPY2R, a region critical for ligand binding and receptor activation. As a control, it helps distinguish specific NPY2R signals from nonspecific background in techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its use is crucial in experiments requiring validation of NPY2R knockout models or receptor localization studies, particularly in brain regions like the hippocampus and hypothalamus. The Npy2r (N-term).ctrl antibody aids in ensuring data reliability by confirming the absence of off-target binding, which is essential given the structural homology among NPY receptor family members. This tool supports research into NPY2R's roles in metabolic disorders, neurodegenerative diseases, and psychiatric conditions.

客户数据及评论

折叠内容

大包装询价

×