| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cardiotrophin-1, CT-1, Ctf1 |
| Entrez GeneID | 13019 |
| WB Predicted band size | 21.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Ctf1 antibody is generated from a rabbit immunized with a recombinant protein. |
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以下是关于小鼠(Mouse)Ctf1抗体的模拟参考文献示例(仅供参考，具体文献可能需要通过学术数据库验证)：
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1. **文献名称**: *"Cardiotrophin-1 Regulates Survival and Hypertrophic Growth of Cardiomyocytes through gp130-Dependent Pathways"*
**作者**: Sheng, Y.; Pennica, D.; Wood, W.I.
**摘要**: 本研究利用小鼠Ctf1特异性抗体，通过Western blot和免疫荧光技术，揭示了Ctf1通过gp130受体信号通路调控心肌细胞存活和肥大性生长的机制。抗体验证显示其在心脏组织中的高特异性。
2. **文献名称**: *"Generation and Characterization of a Monoclonal Antibody Against Mouse Cardiotrophin-1 for In Vivo Neutralization Studies"*
**作者**: Li, X.; Chen, J.; Wang, H.
**摘要**: 报道了一种新型小鼠Ctf1单克隆抗体的开发，该抗体能够有效中和Ctf1活性。通过体外细胞实验和心脏纤维化小鼠模型，证实该抗体可抑制Ctf1介导的STAT3磷酸化。
3. **文献名称**: *"Ctf1 Deficiency Alters Cardiac Development in Mice: Insights from Immunohistochemical Analysis"*
**作者**: Oshima, M.; Yoshida, K.; Akira, S.
**摘要**: 利用Ctf1抗体进行免疫组化分析，发现Ctf1敲除小鼠胚胎心脏发育异常，强调了Ctf1在心脏形态发生中的关键作用，并提供了抗体在组织定位中的应用实例。
4. **文献名称**: *"Role of Cardiotrophin-1 in Obesity-Related Metabolic Inflammation: Antibody-Based Therapeutic Potential"*
**作者**: Zhang, R.; Xu, Q.; Liu, T.
**摘要**: 研究通过小鼠模型证明Ctf1抗体可减轻高脂饮食诱导的代谢炎症，抗体阻断Ctf1后显著降低脂肪组织中炎症因子表达，提示其治疗代谢疾病的潜力。
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**注意**：以上文献为模拟示例，实际文献可能需要通过PubMed、Web of Science或Google Scholar等平台检索(关键词：*Mouse Ctf1 antibody*、*Cardiotrophin-1 antibody*)。建议结合具体研究方向筛选最新或高引文献。
The mouse Ctf1 (Cardiotrophin-1) antibody is a tool used to detect and study Ctf1. a cytokine belonging to the interleukin-6 (IL-6) family. Ctf1 plays a critical role in cellular processes such as cardiac development, neuronal survival, and metabolic regulation. It signals through a receptor complex involving gp130 and leukemia inhibitory factor receptor beta (LIFRβ), activating downstream pathways like JAK/STAT, MAPK, and PI3K/AKT. Research on Ctf1 has focused on its involvement in heart hypertrophy, neuroprotection, and metabolic diseases, making it a target for understanding conditions like heart failure, neurodegenerative disorders, and obesity-related pathologies.
The antibody, typically produced in rabbits or other hosts using immunogenic mouse Ctf1 peptides, enables specific detection of endogenous Ctf1 in murine models. It is widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to investigate Ctf1 expression patterns, tissue localization, and regulatory mechanisms. Studies utilizing this antibody have shed light on Ctf1's dual role in promoting cell survival and apoptosis, depending on cellular context. Its application in knockout or disease models helps clarify Ctf1's physiological functions and therapeutic potential, particularly in cardiovascular and neurological research where Ctf1 dysregulation is implicated.
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