Rabbit Polyclonal INPP5A Antibody

The INPP5A antibody is a research tool designed to detect and study the inositol polyphosphate-5-phosphatase A (INPP5A), an enzyme encoded by the INPP5A gene. INPP5A belongs to the phosphoinositide 5-phosphatase family, which hydrolyzes phosphatidylinositol (4.5)-bisphosphate [PI(4.5)P2] and phosphatidylinositol (3.4.5)-trisphosphate [PI(3.4.5)P3], critical signaling lipids regulating cellular processes like membrane trafficking, cytoskeletal organization, and apoptosis. INPP5A contains a conserved SKIP (SKICH-Phosphatase) domain, linking it to cellular stress responses and protein interactions. Dysregulation of INPP5A has been implicated in neurological disorders, diabetes complications, and cancer, making it a focus of pathophysiological studies. Antibodies targeting INPP5A enable researchers to investigate its expression, localization, and function via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are typically validated for specificity across human, mouse, and rat models, aiding comparative studies. Recent research highlights INPP5A's role in modulating insulin signaling, neuronal development, and tumor suppression, though its mechanisms remain partially elusive. Reliable INPP5A antibodies are crucial for elucidating its regulatory networks and therapeutic potential in disease contexts.