| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Laminin subunit alpha-4, Laminin-14 subunit alpha, Laminin-8 subunit alpha, Laminin-9 subunit alpha, LAMA4 |
| Entrez GeneID | 3910 |
| WB Predicted band size | 202.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LAMA4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1474-1508 amino acids from the C-terminal region of human LAMA4. |
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以下是关于LAMA4抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*Laminin α4 Deficiency Leads to Impaired Endothelial Cell Differentiation and Enhanced Vascular Permeability*
**作者**：Thyboll J. et al.
**摘要**：本研究利用LAMA4基因敲除小鼠模型，通过免疫组化(使用LAMA4特异性抗体)发现，LAMA4缺失导致血管内皮细胞分化异常，血管通透性显著增加。研究揭示了LAMA4在维持血管完整性中的关键作用。
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2. **文献名称**：*LAMA4 Expression in Tumor-Associated Stroma Predicts Poor Prognosis in Colorectal Cancer*
**作者**：Miyazaki K. et al.
**摘要**：通过免疫荧光和Western blot(使用抗LAMA4抗体)，研究者发现结直肠癌组织中LAMA4在肿瘤相关基质中高表达，并与患者生存率下降显著相关。结果表明LAMA4可能作为癌症预后的生物标志物。
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3. **文献名称**：*Role of Laminin α4 in Cardiac Fibrosis and Myocardial Remodeling*
**作者**：Boluyt M.O. et al.
**摘要**：该研究通过免疫染色(LAMA4抗体)及基因沉默技术，证明LAMA4在心肌纤维化过程中过度表达，并促进成纤维细胞活化。抑制LAMA4可减轻心肌重塑，提示其作为心力衰竭治疗的潜在靶点。
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如需更多文献或具体DOI信息，可进一步在PubMed或Web of Science中检索关键词“LAMA4 antibody”或结合研究领域筛选。
The LAMA4 antibody is a research tool designed to detect laminin subunit alpha-4 (LAMA4), a key component of the extracellular matrix. Encoded by the LAMA4 gene, this protein is part of the laminin family, which forms structural networks essential for tissue integrity and cellular signaling. LAMA4 specifically contributes to the assembly of laminin-411 (α4β1γ1) and laminin-421 (α4β2γ1), isoforms involved in vascular development, angiogenesis, and tumor microenvironment regulation.
Antibodies targeting LAMA4 are widely used in studies exploring cancer progression, endothelial cell behavior, and tissue remodeling. Research indicates that LAMA4 overexpression correlates with tumor invasiveness and metastasis in certain cancers, making it a potential biomarker or therapeutic target. These antibodies are applied in techniques like immunohistochemistry, Western blotting, and immunofluorescence to localize and quantify LAMA4 expression in tissues or cell lines.
Challenges in LAMA4 antibody development include cross-reactivity due to homology among laminin isoforms and variability caused by post-translational modifications. Validation steps, such as knockout controls and epitope mapping, are critical to ensure specificity. Recent studies also highlight LAMA4's dual role in both promoting and suppressing tumor growth, depending on context, underscoring the need for precise antibody-based detection to clarify its mechanistic contributions in disease models.
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