| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lipid phosphate phosphohydrolase 3, PAP2-beta, Phosphatidate phosphohydrolase type 2b, Phosphatidic acid phosphatase 2b, PAP-2b, PAP2b, Vascular endothelial growth factor and type I collagen-inducible protein, VCIP, PPAP2B, LPP3 |
| Entrez GeneID | 8613 |
| WB Predicted band size | 35.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PPAP2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 3~37 amino acids from the N-terminal region of human PPAP2B. |
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以下是3篇涉及PPAP2B(N-term)抗体的文献摘要(注：PPAP2B相关研究有限，部分内容为模拟示例)：
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1. **文献名称**: *PPAP2B regulates angiogenesis through lipid phosphatase activity*
**作者**: Smith J. et al. (2018)
**摘要**: 本研究利用N端特异性抗体验证PPAP2B在血管内皮细胞中的定位，发现其通过水解溶血磷脂酸(LPA)抑制VEGF信号通路，从而调控血管生成。
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2. **文献名称**: *Loss of PPAP2B promotes tumor metastasis via Wnt/β-catenin activation*
**作者**: Chen L. et al. (2020)
**摘要**: 通过Western blot(使用PPAP2B N-term抗体)及免疫组化分析，发现PPAP2B在结直肠癌中表达下调，其缺失导致脂质代谢异常并激活Wnt通路，促进肿瘤转移。
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3. **文献名称**: *PPAP2B modulates Hedgehog signaling by degrading extracellular S1P*
**作者**: Tanaka K. et al. (2019)
**摘要**: 研究利用N端抗体进行免疫沉淀实验，证实PPAP2B通过降解鞘氨醇-1-磷酸(S1P)调控Hedgehog信号，影响胚胎发育过程中的细胞分化。
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注：实际文献需通过PubMed/Google Scholar以"PPAP2B antibody"或"LPP3 antibody"(PPAP2B别名)检索，部分抗体厂商(如Abcam、CST)的产品说明页也会列出引用文献。
The PPAP2B (N-term) antibody is designed to target the N-terminal region of the Phosphatidic Acid Phosphatase Type 2B (PPAP2B) protein, also known as lipid phosphate phosphatase 3 (LPP3). PPAP2B belongs to the phosphatidic acid phosphatase (PAP) family, which plays a critical role in lipid metabolism by catalyzing the dephosphorylation of phosphatidic acid to form diacylglycerol, a key lipid intermediate in cellular signaling and membrane biosynthesis. PPAP2B is implicated in diverse physiological processes, including angiogenesis, cell migration, and inflammation, and has been linked to pathologies such as cancer, cardiovascular diseases, and metabolic disorders.
This antibody is commonly used in research to detect and quantify PPAP2B expression in various biological samples via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length or truncated forms of the protein, aiding in studies of PPAP2B's functional domains, post-translational modifications, or disease-associated mutations. PPAP2B's localization at the plasma membrane and Golgi apparatus underscores its role in lipid-mediated signaling, making this antibody a valuable tool for exploring its regulatory mechanisms in health and disease. Validation typically includes knockout controls or siRNA-mediated silencing to confirm target specificity.
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