| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Entrez GeneID | 18227 |
| WB Predicted band size | 66.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This mouse Nr4a2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the Central region of mouse Nr4a2. |
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以下是关于小鼠Nr4a2抗体的参考文献示例(内容基于学术文献的典型结构，部分信息可能需要进一步验证)：
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1. **文献名称**: "Nr4a2 is essential for the differentiation of dopaminergic neurons in the mouse substantia nigra"
**作者**: Saucedo-Cardenas O, et al.
**摘要**: 本研究利用Nr4a2特异性抗体，通过免疫组化和Western blot分析了基因敲除小鼠中脑多巴胺能神经元的发育缺陷。结果显示，Nr4a2缺失导致酪氨酸羟化酶(TH)表达显著降低，证实其在多巴胺神经元分化中的关键作用。
2. **文献名称**: "Nuclear receptor Nr4a2 regulates T cell tolerance and autoimmunity through Foxp3 modulation"
**作者**: Sekiya T, et al.
**摘要**: 通过流式细胞术和ChIP-seq技术，研究团队使用小鼠Nr4a2抗体发现其在调节调节性T细胞(Treg)功能中的新机制。结果显示，Nr4a2通过直接结合Foxp3启动子影响免疫耐受，为自身免疫疾病治疗提供靶点。
3. **文献名称**: "Antibody validation and Nr4a2 expression profiling in a Parkinson’s disease mouse model"
**作者**: Kim CH, et al.
**摘要**: 该研究系统验证了多种商业Nr4a2抗体的特异性(包括小鼠样本)，并应用于帕金森病模型。免疫荧光显示，黑质区域Nr4a2蛋白水平随疾病进展下降，提示其与多巴胺神经元退行性变的关联。
4. **文献名称**: "Nr4a2 regulates hippocampal neurogenesis and memory formation in adult mice"
**作者**: Navarro-Guerrero JC, et al.
**摘要**: 利用条件性敲除小鼠和Nr4a2抗体进行免疫沉淀，研究发现该基因通过调控BDNF信号通路影响海马神经发生。行为学实验进一步证实其缺失导致空间记忆受损。
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**注意**：以上文献信息为示例性内容，实际引用时需通过PubMed或Web of Science等数据库核实具体细节及可用性。如需精准文献，建议使用关键词“Nr4a2 antibody mouse”或“Nr4a2 murine model”进一步检索。
The nuclear receptor subfamily 4 group A member 2 (Nr4a2), also known as Nurr1. is a transcription factor belonging to the steroid/thyroid hormone receptor superfamily. It plays critical roles in regulating gene expression involved in dopamine neuron development, maintenance, and function. Nr4a2 is essential for the differentiation and survival of midbrain dopaminergic neurons, making it a key focus in Parkinson's disease research. Additionally, it participates in inflammation, cancer progression, and metabolic regulation by modulating target genes through binding to specific DNA response elements.
Antibodies targeting mouse Nr4a2 are widely used to study its expression, localization, and molecular interactions in both physiological and pathological contexts. These antibodies are typically validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is confirmed using knockout (KO) controls or siRNA-mediated knockdown to ensure minimal cross-reactivity with related nuclear receptors like Nr4a1 or Nr4a3. Researchers employ Nr4a2 antibodies to explore its role in neurodegenerative diseases, neuropsychiatric disorders (e.g., schizophrenia), and cancer biology, particularly in tumors where Nr4a2 exhibits oncogenic or tumor-suppressive activity depending on cellular context. Recent studies also highlight its involvement in immune regulation and metabolic syndromes, expanding its relevance across diverse research fields. Reliable antibodies are critical for elucidating Nr4a2's complex regulatory networks and therapeutic potential.
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