| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uroplakin-2, UP2, Uroplakin II, UPII, UPK2 |
| Entrez GeneID | 7379 |
| WB Predicted band size | 19.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This UPK2 antibody is generated from a rabbit immunized with recombinant protein. |
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以下是几篇关于UPK2(uroplakin 2)抗体的示例文献(内容为模拟示例，具体文献请通过学术数据库查询)：
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1. **文献名称**: *Uroplakin 2 as a Biomarker for Bladder Cancer Detection*
**作者**: Wu XR, et al.
**摘要**: 该研究验证了UPK2抗体在膀胱癌组织中的特异性表达，发现UPK2可作为尿路上皮癌的潜在诊断标志物，并通过免疫组化分析证明其在肿瘤组织中的高敏感性。
2. **文献名称**: *Characterization of Uroplakin 2-Specific Antibodies in Urinary Tract Pathologies*
**作者**: Smith JL, et al.
**摘要**: 文章系统评估了UPK2抗体在正常与病变尿路上皮中的表达差异，发现其在膀胱炎和低级别肿瘤中的表达下调，提示其与疾病进展相关。
3. **文献名称**: *Role of Uroplakins in Cell-Cell Adhesion: Insights from UPK2 Knockout Models*
**作者**: Tanaka M, et al.
**摘要**: 利用UPK2抗体研究基因敲除小鼠模型，发现UPK2缺失导致尿路上皮屏障功能受损，揭示了其在维持细胞间粘附中的作用。
4. **文献名称**: *Development of a Novel Monoclonal Antibody Against UPK2 for Therapeutic Targeting*
**作者**: Chen H, et al.
**摘要**: 研究报道了一种新型UPK2单克隆抗体的开发，并通过体外实验证明其能特异性结合肿瘤细胞，为靶向治疗提供了实验依据。
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建议通过PubMed、Web of Science等平台搜索关键词“UPK2 antibody”或“uroplakin 2”获取真实文献。
The UPK2 antibody targets uroplakin II, a transmembrane protein component of the urothelial plaque in the urinary tract. Uroplakins (UPKs), including UPK2. are critical for maintaining the permeability barrier and mechanical stability of the urothelium, the specialized epithelium lining the bladder, ureters, and renal pelvis. UPK2 forms heterodimers with UPK1a or UPK1b, contributing to the asymmetric unit membrane (AUM) structure that protects against urine-induced damage.
Antibodies against UPK2 are widely used in research and diagnostics to study urothelial differentiation, integrity, and pathologies. They help identify urothelial cells in tissue samples and are instrumental in diagnosing urothelial carcinomas, as UPK2 expression is often downregulated in aggressive bladder cancers. Additionally, UPK2 antibodies aid in investigating congenital bladder disorders and urinary tract infections linked to urothelial dysfunction.
Commercially available UPK2 antibodies (polyclonal or monoclonal) are validated for techniques like immunohistochemistry, Western blotting, and flow cytometry. Their specificity makes them valuable tools for exploring urothelial biology, cancer biomarkers, and therapeutic targets. However, cross-reactivity with other uroplakins or species variations requires careful validation in experimental settings.
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