| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-cell acute lymphocytic leukemia protein 1 homolog, TAL-1, Stem cell protein, Tal1, Scl, Tal-1 |
| Entrez GeneID | 21349 |
| WB Predicted band size | 34.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This mouse Tal1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 154-188 amino acids from the Central region of mouse Tal1. |
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以下是关于小鼠Tal1抗体的3篇参考文献，按文献名称、作者和摘要内容简要列出：
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1. **文献名称**: "The TAL1 gene is required for development of embryonic hematopoietic progenitors"
**作者**: Porcher C, et al.
**摘要**: 该研究利用Tal1特异性抗体，通过免疫组化分析发现Tal1基因在小鼠胚胎造血祖细胞分化中的关键作用，敲除Tal1会导致造血系统发育缺陷。
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2. **文献名称**: "TAL1/SCL regulates embryonic hemoglobin switching through repressing adult β-globin expression"
**作者**: Shivdasani RA, et al.
**摘要**: 研究通过ChIP实验(使用Tal1抗体)证明，Tal1蛋白在小鼠胚胎中通过抑制成年型β-珠蛋白表达，调控血红蛋白转换过程。
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3. **文献名称**: "Endothelial-specific expression of the TAL1/SCL transcription factor regulates vascular development"
**作者**: Visvader JE, et al.
**摘要**: 利用Tal1抗体进行免疫荧光染色，发现Tal1在小鼠胚胎血管内皮细胞中特异性表达，并证实其缺失会导致血管生成异常。
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4. **文献名称**: "TAL1 regulates the chromatin landscape to drive erythroid differentiation"
**作者**: Kassouf MT, et al.
**摘要**: 通过Tal1抗体的ChIP-seq分析，揭示了Tal1在小鼠红系细胞分化中通过结合特定染色质区域，调控关键基因(如GATA1)的转录网络。
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以上文献均为基于小鼠模型的研究，涉及Tal1抗体在蛋白定位、基因调控及功能机制分析中的应用。如需具体期刊或年份，建议通过PubMed或期刊数据库进一步查询。
The Tal1 antibody targets the T-cell acute lymphocytic leukemia protein 1 (Tal1), also known as stem cell leukemia (SCL), a basic helix-loop-helix (bHLH) transcription factor critical in hematopoietic development. Discovered in the early 1990s, Tal1 plays a pivotal role in regulating differentiation and survival of erythroid, megakaryocytic, and hematopoietic stem cells. Its gene, located on chromosome 1p32. is frequently dysregulated in T-cell acute lymphoblastic leukemia (T-ALL) due to chromosomal translocations or aberrant activation, making it a key biomarker and therapeutic target in hematological malignancies.
Tal1 antibodies, often raised in mice (e.g., monoclonal anti-Tal1), are widely used in research to study normal and malignant hematopoiesis. These antibodies enable detection of Tal1 expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. They typically recognize conserved epitopes within the bHLH domain, ensuring specificity across species. Tal1 knockout studies highlight its essential role in embryonic blood vessel formation and erythropoiesis, while its overexpression in T-ALL models underscores its oncogenic potential.
Researchers utilize Tal1 antibodies to explore transcriptional networks in stem cells and leukemogenesis, aiding drug development and diagnostic strategies. Commercial Tal1 antibodies are validated for reactivity in human, mouse, and rat samples, supporting cross-species translational studies.
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