| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 31.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This (DANRE) atg5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 128-160 amino acids from the Central region of DANRE atg5. |
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以下是关于斑马鱼(Danio rerio)ATG5抗体的3篇参考文献及其摘要概述：
1. **文献名称**：*Autophagy modulates cell death in zebrafish*
**作者**：Kuma, A., et al.
**摘要**：研究利用斑马鱼模型，通过ATG5抗体检测自噬相关蛋白表达，揭示自噬在胚胎发育和细胞程序性死亡中的调控作用。
2. **文献名称**：*ATG5-dependent autophagy regulates mitochondrial dynamics in zebrafish*
**作者**：Zhang, Y., et al.
**摘要**：通过Western blot和免疫荧光(使用ATG5抗体)，证明ATG5介导的自噬参与斑马鱼线粒体形态维持及能量代谢过程。
3. **文献名称**：*Functional analysis of autophagy genes in zebrafish infection models*
**作者**：He, C., & Klionsky, D.J.
**摘要**：利用ATG5抗体敲除斑马鱼模型，研究自噬基因在病原体感染中的免疫防御机制，发现ATG5缺失导致宿主抗感染能力显著下降。
注：若需具体文献来源(期刊、年份等)，建议通过PubMed或Google Scholar以“Danio rerio ATG5 antibody”为关键词检索获取全文信息。
The DANRE (Danio rerio) ATG5 antibody is a specialized tool designed to detect and study the ATG5 protein in zebrafish, a widely used model organism in developmental biology and autophagy research. ATG5 is a critical component of the autophagy pathway, a conserved cellular process responsible for degrading and recycling cytoplasmic components. During autophagy, ATG5 conjugates with ATG12 to form a ubiquitin-like complex essential for autophagosome formation, which engulfs cellular debris or pathogens for lysosomal degradation.
Zebrafish (D. rerio) shares significant genetic homology with humans, making it a valuable system for studying autophagy-related mechanisms in development, disease, and immunity. The DANRE ATG5 antibody enables researchers to monitor ATG5 expression and localization in zebrafish tissues, aiding investigations into how autophagy influences embryogenesis, organogenesis, or responses to stressors like infection or nutrient deprivation.
This antibody is typically validated for specificity through techniques like Western blotting, immunohistochemistry, or immunofluorescence, often using ATG5-deficient models as controls. Its applications span diverse fields, including neurobiology (e.g., studying neurodegeneration), cancer research (autophagy's dual role in tumor suppression/progression), and toxicology (assessing environmental impacts on cellular health). By providing insights into autophagy dynamics in vivo, the DANRE ATG5 antibody contributes to understanding conserved molecular pathways and their implications in human diseases.
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