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Rabbit Polyclonal LHX5 Antibody

  • 中文名: LHX5抗体
  • 别    名: LIM/homeobox protein Lhx5, LIM homeobox protein 5, LHX5
货号: IPDX32999
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesLIM/homeobox protein Lhx5, LIM homeobox protein 5, LHX5
Entrez GeneID64211
WB Predicted band size44.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis LHX5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 255-289 amino acids from the Central region of human LHX5.

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参考文献

以下是关于LHX5抗体的3篇参考文献摘要(基于公开研究主题整理,具体文献需通过数据库验证):

1. **文献名称**:*"LHX5 regulates the differentiation of cortical progenitor cells in the developing mouse brain"*

**作者**:Zhao Y, et al.

**摘要**:该研究利用LHX5抗体进行免疫组化染色,揭示了LHX5在小鼠胚胎皮层发育中的表达模式,证明其通过调控下游靶基因参与神经前体细胞的命运决定和分层皮层组织的形成。

2. **文献名称**:*"LHX5 and HMGA2 co-regulate the maintenance of neural stem cells in the hippocampal dentate gyrus"*

**作者**:Lee SM, et al.

**摘要**:通过LHX5抗体的Western blot和免疫荧光实验,研究发现LHX5与HMGA2协同作用维持海马区神经干细胞的自我更新能力,缺失LHX5会导致成年神经发生异常。

3. **文献名称**:*"Aberrant LHX5 expression in human focal cortical dysplasia and epilepsy"*

**作者**:Smith J, et al.

**摘要**:使用LHX5抗体对癫痫患者脑组织样本进行染色,发现皮质发育畸形区域中LHX5表达显著降低,提示其表达异常可能与神经元迁移障碍及癫痫发生相关。

4. **文献名称**:*"LHX5 interacts with the NuRD complex to silence gene expression during neuronal maturation"*

**作者**:Chen R, et al.

**摘要**:通过免疫共沉淀(结合LHX5抗体)和ChIP-seq技术,揭示了LHX5在神经元成熟过程中招募NuRD复合体以抑制特定基因表达,调控突触可塑性的分子机制。

**注意**:以上内容为模拟摘要,实际文献请通过PubMed、Google Scholar等平台以“LHX5 antibody”或“LHX5 function”为关键词检索获取。

背景信息

The LHX5 antibody is a crucial tool in neuroscience and developmental biology research, targeting the LIM-homeodomain transcription factor LHX5. This protein belongs to the LIM-homeobox (LHX) family, which plays pivotal roles in cell fate specification, neuronal differentiation, and embryonic development. LHX5 is particularly implicated in forebrain development, hippocampal formation, and spinal cord patterning, with expression patterns observed in specific neuronal populations during embryogenesis. Researchers utilize LHX5 antibodies primarily in techniques like immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF) to map protein localization, track developmental changes, and investigate neurodevelopmental disorders. The antibody's specificity is validated through knockout controls or siRNA-mediated protein knockdown. Commercially available LHX5 antibodies are typically raised in rabbits or mice using recombinant protein fragments or peptide antigens. Recent studies employing these antibodies have uncovered LHX5's involvement in GABAergic interneuron migration, synaptic plasticity, and its potential link to epilepsy and intellectual disability. Proper validation remains essential due to potential cross-reactivity with structurally similar LHX family members like LHX1 or LHX6. These reagents continue to advance our understanding of neural circuit assembly and congenital brain malformations.

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