Rabbit Polyclonal MouseLhx1 Antibody

The Lhx1 antibody is a valuable tool in developmental biology research, specifically targeting the LIM-homeobox transcription factor Lhx1 (also known as Lim1) in mice. Lhx1 plays a critical role in embryonic development, including neural tube formation, kidney organogenesis, and the specification of anterior head structures. It regulates gene expression by binding to DNA through its homeodomain and interacting with other proteins via its LIM domains. Mouse Lhx1 antibodies are typically raised against specific epitopes of the murine Lhx1 protein, enabling the detection and localization of Lhx1 in tissue samples, cell lysates, or during protein-protein interaction studies. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate Lhx1's expression patterns and functional roles in developmental processes. Researchers often validate antibody specificity using knockout controls or siRNA-mediated knockdowns to ensure minimal cross-reactivity with related LIM-homeodomain proteins. Studies utilizing Mouse Lhx1 antibodies have contributed to understanding congenital anomalies, such as kidney agenesis and neurological defects, linked to Lhx1 dysregulation. Commercial antibodies are commonly generated in hosts like rabbits or mice, with clonal types ranging from monoclonal to polyclonal, each offering distinct advantages in sensitivity and application flexibility.