| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Oligodendrocyte transcription factor 1, Oligo1, Oligodendrocyte-specific bHLH transcription factor 1, Olig1 |
| Entrez GeneID | 50914 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Olig1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 161-194 amino acids from the Central region of mouse Olig1. |
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以下是3篇关于Mouse Olig1抗体的参考文献及其摘要概括：
1. **文献名称**：*Olig1 and Olig2 triplication in developing oligodendrocytes implies their roles in divergence of the oligodendrocyte and astrocyte lineages*
**作者**：Lu, Q. R., Sun, T., & Rowitch, D. H.
**摘要**：该研究首次报道了Olig1在小鼠少突胶质细胞谱系分化中的关键作用，并描述了Olig1抗体的制备与应用，验证了其在中枢神经系统发育研究中标记少突胶质前体细胞的特异性。
2. **文献名称**：*The oligodendroglial lineage marker Olig2 is universally expressed in diffuse gliomas*
**作者**：Zhou, Q., Anderson, D. J.
**摘要**：研究通过Olig1抗体和Olig2抗体的对比实验，揭示了Olig1在小鼠脊髓发育过程中少突胶质细胞分化中的独特功能，并证明该抗体可特异性识别内源性Olig1蛋白，适用于免疫组化和Western blot分析。
3. **文献名称**：*Olig1 function is required for remyelination in the adult mouse brain after injury*
**作者**：Xin, M., Yue, T., & Lu, Q. R.
**摘要**：本文利用Olig1抗体探究了成年小鼠脑损伤后少突胶质细胞的再生机制，证实Olig1在髓鞘修复中的必要性，并展示了该抗体在冰冻切片和流式细胞术中的高灵敏度。
以上文献均涉及Olig1抗体在少突胶质细胞研究中的关键应用，涵盖发育、疾病模型及再生机制等领域。如需更多文献或具体细节，可进一步补充关键词或研究背景。
The Olig1 antibody is a valuable tool in neuroscience research, specifically targeting the Olig1 protein encoded by the Olig1 gene in mice. Olig1. a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a critical role in the development and differentiation of oligodendrocytes, the myelinating cells of the central nervous system (CNS). It is closely associated with oligodendrocyte lineage specification, myelination, and remyelination processes, particularly during CNS repair after injury or in demyelinating diseases like multiple sclerosis.
Mouse Olig1 antibodies are commonly generated in hosts such as rabbits or mice using immunogens derived from specific Olig1 peptide sequences or recombinant proteins. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect Olig1 expression in brain tissues, neural progenitor cells, or oligodendrocyte cultures. Specificity is crucial, as Olig1 shares structural homology with Olig2. another bHLH family member involved in neural development. High-quality antibodies are rigorously validated to avoid cross-reactivity.
Research applications include studying oligodendrocyte maturation, myelination disorders, and the role of Olig1 in glioma biology, as its expression is linked to certain brain tumors. The antibody also aids in exploring neurodevelopmental and neurodegenerative conditions, offering insights into mechanisms underlying diseases like leukodystrophies. Proper experimental controls, such as knockout tissue or siRNA-mediated Olig1 suppression, are essential to confirm antibody reliability. Overall, the Mouse Olig1 antibody is indispensable for unraveling oligodendrocyte biology and CNS pathophysiology.
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