| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase Fgr, Proto-oncogene c-Fgr, p55-Fgr, Fgr |
| Entrez GeneID | 14191 |
| WB Predicted band size | 58.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Fgr antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 232-265 amino acids from the Central region of Mouse Fgr. |
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以下是关于小鼠Fgr抗体的模拟参考文献示例(非真实存在，仅供格式参考)：
1. **文献名称**: *"Fgr Kinase Regulates TLR4 Signaling in Macrophages via MyD88 Phosphorylation"*
**作者**: Smith A, et al.
**摘要**: 研究利用小鼠Fgr特异性抗体进行Western blot和免疫沉淀，发现Fgr通过磷酸化MyD88调控TLR4信号通路，影响巨噬细胞炎症因子释放。
2. **文献名称**: *"Defective Neutrophil Chemotaxis in Fgr-Deficient Mice Revealed by Antibody-Based Tracking"*
**作者**: Chen L, et al.
**摘要**: 通过Fgr抗体检测基因敲除小鼠中性粒细胞中的蛋白缺失，证实Fgr缺失导致细胞迁移能力下降，并影响NADPH氧化酶活性。
3. **文献名称**: *"Targeting Fgr with Monoclonal Antibody Attenuates Arthritis in Murine Models"*
**作者**: Tanaka K, et al.
**摘要**: 开发抗小鼠Fgr单克隆抗体，体内实验显示其通过阻断Fgr与Syk相互作用抑制关节炎症，为自身免疫疾病治疗提供新策略。
4. **文献名称**: *"Fgr Antibody-Based Inhibition Suppresses Viral Replication in Influenza-Infected Mice"*
**作者**: Rodriguez M, et al.
**摘要**: 研究使用Fgr中和抗体干预流感病毒感染，发现其通过降低STAT1磷酸化水平抑制病毒复制，提示Fgr在抗病毒免疫中的潜在靶点价值。
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注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词(如 "Fgr kinase antibody mouse")获取。若需真实文献，可提供具体数据库访问协助。
The mouse Fgr antibody is a research tool designed to detect and analyze the Fgr protein (also known as Src2 or p59-Fgr) in murine models. Fgr, a member of the Src family of tyrosine kinases (SFK), is primarily expressed in hematopoietic cells, including macrophages, neutrophils, and B lymphocytes. It plays roles in immune cell signaling, adhesion, and activation by regulating downstream pathways such as MAPK and PI3K/AKT. Dysregulation of Fgr has been implicated in inflammatory diseases, autoimmune disorders, and hematologic malignancies.
The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study Fgr's expression, localization, and interaction partners in biological samples. Its specificity for the mouse homolog makes it valuable for preclinical studies using murine disease models, such as leukemia, chronic inflammation, or infection. Researchers also utilize Fgr antibodies to explore the kinase's role in Fcγ receptor-mediated phagocytosis, cytokine production, and osteoclast function.
Developed through immunization with recombinant mouse Fgr antigens, these antibodies help dissect Fgr's dual role as both an oncogene and a regulator of innate immunity. Their applications extend to evaluating therapeutic inhibitors targeting SFK signaling pathways in cancer and autoimmune research.
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