| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Forkhead box protein N4, FOXN4 |
| Entrez GeneID | 121643 |
| WB Predicted band size | 55.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FOXN4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 314-349 amino acids from the Central region of human FOXN4. |
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以下是关于FOXN4抗体的3篇参考文献及其摘要内容(文献信息为虚构示例，仅供格式参考)：
1. **文献名称**：*FOXN4 regulates neuronal differentiation via antibody-validated protein interactions*
**作者**：Li, X. et al.
**摘要**：本研究利用特异性FOXN4抗体，通过免疫共沉淀技术揭示了FOXN4在神经元分化中与Notch信号通路蛋白的相互作用，证实其通过调控靶基因转录影响神经前体细胞命运。
2. **文献名称**：*Development and application of a monoclonal antibody for FOXN4 in pancreatic cancer models*
**作者**：Martinez, R. & Chen, H.
**摘要**：报道了一种新型FOXN4单克隆抗体的开发，验证了其在人胰腺癌组织中的高特异性染色能力，并发现FOXN4表达缺失与肿瘤侵袭性相关。
3. **文献名称**：*FOXN4 antibody-based screening identifies its role in zebrafish thymus development*
**作者**：Wang, Y. et al.
**摘要**：通过斑马鱼模型结合FOXN4抗体的免疫荧光染色，证明FOXN4在胸腺上皮细胞分化中起关键作用，缺失导致T细胞发育异常。
(注：以上文献为模拟示例，实际文献需通过PubMed/Google Scholar等平台以“FOXN4 antibody”为关键词检索获取。)
The FOXN4 antibody is a tool used to study the FOXN4 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXN4 plays a critical role in regulating gene expression during development, particularly in organogenesis and cell differentiation. It is notably involved in the development of the thymus, where it influences the maturation of thymic epithelial cells (TECs), essential for T-cell development. FOXN4 also contributes to pancreatic and nervous system development. Dysregulation or mutations in FOXN4 have been linked to developmental disorders, immune deficiencies, and certain cancers, such as squamous cell carcinoma.
Researchers use FOXN4 antibodies primarily in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect FOXN4 expression patterns in tissues or cell lines. These studies help elucidate its role in developmental pathways, tissue homeostasis, and disease mechanisms. Commercially available FOXN4 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation includes testing for specificity via knockout controls or siRNA knockdown. Understanding FOXN4's regulatory networks through such antibodies provides insights into therapeutic strategies for immune disorders, congenital defects, and malignancies associated with FOXN4 dysfunction.
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