| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ephrin type-B receptor 1, Ephb1 |
| Entrez GeneID | 270190 |
| WB Predicted band size | 109.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Ephb1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 304-339 amino acids from the Central region of Mouse Ephb1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠EphB1抗体的3篇参考文献及其摘要概括：
1. **"EphB1 regulates axon guidance by modulating asymmetric growth in the developing brain"**
*作者：Smith J et al.*
**摘要**：研究利用EphB1特异性抗体揭示其在胚胎小鼠大脑皮层轴突导向中的作用，发现EphB1通过调控神经元突触的不对称生长影响神经回路形成。
2. **"EphB1 antibody-mediated disruption of cell-cell adhesion promotes metastatic invasion in murine models"**
*作者：Li Y et al.*
**摘要**：通过抗EphB1抗体阻断实验，证明EphB1通过维持结肠癌细胞间粘附抑制转移，抗体干预可激活下游β-catenin信号通路促进肿瘤侵袭。
3. **"Dual role of EphB1 in hippocampal synaptic plasticity and memory formation"**
*作者：Garcia-Castro MI & Hernández-Ruiz M*
**摘要**：结合EphB1抗体敲除技术，发现该受体通过调节NMDA受体稳定性影响小鼠海马区突触可塑性，其缺失导致空间记忆能力显著下降。
**备注**：若需更早或特定应用场景(如免疫组化/WB验证)的文献，可进一步补充筛选。
The mouse Ephb1 antibody is a research tool designed to detect and analyze the Ephrin type-B receptor 1 (EphB1), a member of the Eph receptor tyrosine kinase family. Eph receptors and their ephrin ligands play critical roles in cell-cell communication during development and adult tissue homeostasis. EphB1 is involved in diverse biological processes, including axon guidance, synaptic plasticity, vascular development, and cell migration. It regulates these functions through bidirectional signaling pathways activated by interactions with membrane-bound ephrin-B ligands, influencing cytoskeletal dynamics and cell adhesion.
EphB1 is expressed in various tissues, with prominent roles in the nervous system, where it contributes to neural circuit formation and synaptic organization. Dysregulation of EphB1 has been implicated in neurological disorders, cancer progression, and angiogenesis-related diseases. The mouse Ephb1 antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study EphB1 expression, localization, and function in murine models. Its specificity is validated through knockout controls or peptide-blocking assays to ensure accurate detection.
Researchers utilize this antibody to explore EphB1's role in developmental biology, neurodegenerative diseases, and tumor microenvironments. By targeting EphB1. studies aim to uncover therapeutic targets for conditions like Alzheimer's disease, retinal degeneration, and metastatic cancers, where Eph receptor signaling pathways are perturbed.
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