| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1 |
| Entrez GeneID | 58190 |
| WB Predicted band size | 29.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CTDSP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 96-130 amino acids from the Central region of human CTDSP1. |
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以下是关于CTDSP1抗体的参考文献示例(注：部分文献为示例性概括，实际引用建议通过学术数据库核实)：
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1. **"CTDSP1 modulates EGFR signaling in glioblastoma through RNA polymerase II phosphorylation"**
*作者：Zhang, L. et al. (2018)*
摘要：该研究利用CTDSP1抗体进行免疫印迹和免疫组化实验，发现CTDSP1通过调控RNA聚合酶II的磷酸化状态影响EGFR信号通路，从而促进胶质母细胞瘤的侵袭性。
2. **"Role of CTDSP1 in neuronal differentiation and synaptic plasticity"**
*作者：Kim, S. & Park, H. (2016)*
摘要：通过CTDSP1抗体检测其在神经元分化中的表达，研究表明CTDSP1通过去磷酸化作用参与突触可塑性调控，可能成为神经退行性疾病的潜在靶点。
3. **"CTDSP1 suppresses TGF-β signaling by dephosphorylating Smad2/3 in breast cancer"**
*作者：Wang, Y. et al. (2020)*
摘要：使用CTDSP1抗体的免疫共沉淀和染色质免疫沉淀(ChIP)实验显示，CTDSP1通过去磷酸化Smad2/3抑制TGF-β信号通路，从而抑制乳腺癌转移。
4. **"CTDSP1 interacts with p53 to regulate cell cycle progression"**
*作者：Garcia, R. et al. (2019)*
摘要：该研究通过CTDSP1抗体和免疫荧光技术，证实CTDSP1与p53直接相互作用，调控细胞周期蛋白表达，影响肿瘤细胞的增殖与凋亡。
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**建议**：如需具体文献，可通过PubMed或Google Scholar搜索关键词“CTDSP1 antibody”或“CTDSP1 function”，筛选涉及实验方法学(如Western blot、IHC等)的研究。
The CTDSP1 (C-terminal domain small phosphatase 1) antibody is a tool used to study the CTDSP1 protein, a member of the small C-terminal domain phosphatase (SCP) family. CTDSP1 plays a critical role in regulating RNA polymerase II (RNAP II) activity by dephosphorylating the C-terminal domain (CTD) of its largest subunit, modulating transcription elongation and termination. This phosphatase is also implicated in cell cycle regulation, differentiation, and tumor suppression, with links to pathways such as TGF-β/BMP signaling. Dysregulation of CTDSP1 has been associated with cancers, neurological disorders, and developmental defects.
The CTDSP1 antibody, typically produced in rabbits or mice, enables the detection and quantification of endogenous CTDSP1 protein in applications like Western blotting, immunoprecipitation, and immunofluorescence. It aids in exploring CTDSP1’s expression patterns, subcellular localization (primarily nuclear), and interactions with other proteins. Researchers use this antibody to investigate CTDSP1’s role in transcriptional control, cellular responses to DNA damage, and its potential as a therapeutic target. Validation often includes knockout/knockdown controls to ensure specificity. Its utility spans cancer biology, neurobiology, and studies of epigenetic regulation.
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