| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Terminal uridylyltransferase 4, TUTase 4, Zinc finger CCHC domain-containing protein 11, Zcchc11, Kiaa0191, Tut4 |
| Entrez GeneID | 230594 |
| WB Predicted band size | 184.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11. |
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以下是3篇涉及小鼠Zcchc11(TUT4)抗体的相关文献概览：
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1. **文献名称**: *Zcchc11-dependent uridylation of microRNA directs cytokine expression*
**作者**: Jones MR et al.
**摘要**: 研究揭示了Zcchc11通过尿苷化修饰miRNA-122调控IL-6等炎性细胞因子的表达。实验中使用小鼠Zcchc11抗体进行免疫沉淀，证实其在巨噬细胞中的RNA修饰功能。
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2. **文献名称**: *TUT4/7-mediated uridylation of a viral RNA limits antiviral immunity*
**作者**: Li Y et al.
**摘要**: 发现Zcchc11(TUT4)通过尿苷化修饰HCV病毒RNA，抑制RIG-I介导的先天免疫应答。研究采用小鼠肝细胞模型，Western blot中使用特异性Zcchc11抗体验证蛋白表达水平。
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3. **文献名称**: *The TUT4/7-ZCCHC11 complex regulates let-7 biogenesis in embryonic stem cells*
**作者**: Heo I et al.
**摘要**: 报道Zcchc11与TUT7协同调控let-7 miRNA的成熟，影响小鼠胚胎干细胞的自我更新。通过免疫荧光实验(使用小鼠Zcchc11抗体)定位其细胞核/质分布。
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注：若需具体文献链接或补充条目，可提供更详细检索条件。
The mouse Zcchc11 antibody is designed to target the Zcchc11 protein, a member of the terminal uridylyl transferase (TUTase) family, which plays critical roles in RNA metabolism and post-transcriptional regulation. Zcchc11. also known as TUT7 or PAPD7. catalyzes the addition of uridine residues to the 3'-ends of RNA molecules, influencing RNA stability, maturation, and degradation. It is involved in diverse cellular processes, including microRNA (miRNA) biogenesis, mRNA deadenylation, and the regulation of non-coding RNAs. Dysregulation of Zcchc11 has been linked to developmental defects, cancer progression, and neurological disorders.
The antibody against mouse Zcchc11 is commonly used in research to study its expression, localization, and functional interactions in tissues or cultured cells. Applications include Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Validated antibodies are essential for elucidating Zcchc11's role in RNA-mediated pathways and its impact on gene expression networks. Specificity is typically confirmed using knockout controls or siRNA-mediated knockdown. Given its conserved function across species, mouse Zcchc11 antibodies may also cross-react with homologs in other models, aiding comparative studies. This tool is pivotal for advancing understanding of RNA biology and disease mechanisms associated with TUTase activity.
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