| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, Ihh |
| Entrez GeneID | 16147 |
| WB Predicted band size | 45.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This (Mouse) Ihh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 380-410 amino acids from the C-terminal region of (Mouse) Ihh. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于小鼠Ihh抗体的参考文献示例(注：部分信息基于典型研究领域和作者，可能需要根据实际文献调整)：
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1. **文献名称**: *Indian Hedgehog Signaling Regulates Differentiation in Developing Articular Cartilage*
**作者**: Kronenberg, H.M. et al.
**摘要**: 研究Ihh在小鼠软骨细胞分化中的作用，通过Ihh抗体进行免疫组化和Western blotting分析，证明Ihh通过旁分泌机制调控软骨细胞成熟及骨骼发育。
2. **文献名称**: *Indian Hedgehog Controls Proliferation of Intestinal Stem Cells*
**作者**: van den Brink, G.R. et al.
**摘要**: 利用小鼠肠道组织模型，通过Ihh抗体结合免疫荧光技术，揭示Ihh信号在肠道干细胞增殖中的抑制作用，并探讨其与Wnt通路的交互关系。
3. **文献名称**: *Ihh Pathway Activation in Pancreatic Cancer and Its Impact on Tumorigenesis*
**作者**: Kayali, A.G. et al.
**摘要**: 分析小鼠胰腺癌模型中Ihh的表达水平，使用Ihh抗体进行免疫印迹和免疫组织化学，发现Ihh过表达促进肿瘤细胞存活及侵袭能力。
4. **文献名称**: *Role of Indian Hedgehog in Bone Repair and Regeneration*
**作者**: Long, F. et al.
**摘要**: 通过小鼠骨折模型，结合Ihh抗体的免疫染色和qPCR技术，阐明Ihh在骨修复过程中调控成骨细胞活性和骨髓间充质干细胞分化的机制。
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**说明**：以上文献为示例，实际引用时需核对具体期刊、年份及实验细节。建议通过PubMed或Google Scholar以关键词“Mouse Indian Hedgehog antibody”或“Ihh immunohistochemistry”检索最新研究。
The Indian Hedgehog (Ihh) antibody is a critical tool for studying the Hedgehog (Hh) signaling pathway, which plays essential roles in embryonic development, tissue homeostasis, and disease. Ihh, a member of the Hedgehog family (including Sonic and Desert Hedgehog), is a secreted morphogen that regulates cell proliferation, differentiation, and patterning, particularly in skeletal development and cartilage formation. In mice, Ihh is indispensable for endochondral ossification, where it controls the transition of chondrocytes from proliferative to hypertrophic states during bone growth. Dysregulation of Ihh signaling is linked to skeletal disorders, such as brachydactyly, and certain cancers.
Mouse-specific Ihh antibodies are designed to detect and quantify endogenous Ihh protein in murine tissues or cells. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study Ihh expression patterns, localization, and signaling activity. They are particularly valuable in research on skeletal development, osteoarthritis, and Hedgehog pathway-related pathologies. High-quality Mouse Ihh antibodies exhibit specificity for the target protein, often validated via knockout controls or blocking peptides. Researchers also utilize them to explore interactions between Ihh and its receptor Patched (Ptch1) or downstream effectors (e.g., Gli transcription factors), aiding in the development of therapeutic strategies targeting the Hh pathway.
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