Rabbit Polyclonal PAXIP1(N-term) Antibody

The PAXIP1 (N-term) antibody is a valuable tool for studying the Pax transactivation domain-interacting protein 1 (PAXIP1), also known as PTIP, which plays critical roles in DNA damage repair, transcriptional regulation, and chromatin remodeling. PAXIP1 interacts with histone-modifying complexes, including the MLL/COMPASS family, to facilitate histone H3K4 methylation, influencing gene expression and genome stability. It also participates in the DNA damage response by recruiting repair factors to sites of double-strand breaks. The N-terminal region of PAXIP1 contains key functional domains involved in protein-protein interactions and complex assembly. The PAXIP1 (N-term) antibody specifically targets epitopes within this region, enabling researchers to detect full-length PAXIP1 and investigate its expression, localization, and interactions in various cellular contexts. Applications include Western blotting, immunoprecipitation, and immunofluorescence, aiding studies on PAXIP1's roles in development, cancer (e.g., tumor suppression or therapy resistance), and neurological disorders. Validated for specificity in multiple species, this antibody is widely used to explore PAXIP1's molecular mechanisms in maintaining genomic integrity and regulating epigenetic signaling pathways.