Rabbit Polyclonal HLA-DRB1 Antibody

The HLA-DRB1 gene, part of the human leukocyte antigen (HLA) complex on chromosome 6. encodes a key component of MHC class II molecules critical for adaptive immunity. These molecules present exogenous antigens to CD4+ T cells, initiating immune responses. HLA-DRB1 exhibits extreme polymorphism, with over 2.000 documented alleles, influencing antigen-binding specificity and disease susceptibility. Antibodies targeting HLA-DRB1 typically arise from exposure to non-self HLA antigens through events like pregnancy, blood transfusions, or organ transplantation. In transplant medicine, anti-HLA-DRB1 antibodies are clinically significant as they can trigger graft rejection by binding to donor endothelial cells, activating complement pathways, and promoting inflammation. Their detection via solid-phase assays (e.g., Luminex) is standard in pre-transplant risk assessment. Beyond transplantation, specific HLA-DRB1 alleles (*04:01. *04:04. *01:01) are strongly linked to autoimmune disorders like rheumatoid arthritis, where molecular mimicry between foreign antigens and self-peptides may drive pathogenic antibody production. Research also explores their role in drug hypersensitivity and infection outcomes. Understanding HLA-DRB1 antibody dynamics remains vital for improving transplant success and unraveling autoimmune pathogenesis.