| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-soluble NSF attachment protein, SNAP-gamma, N-ethylmaleimide-sensitive factor attachment protein gamma, NAPG, SNAPG |
| Entrez GeneID | 8774 |
| WB Predicted band size | 34.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This NAPG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 119-152 amino acids from the Central region of human NAPG. |
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以下是关于NAPG抗体的3篇文献示例(注：以下内容为模拟构造，实际文献需通过学术数据库查询确认)：
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1. **文献名称**: "NAPG Antibody-Based Detection of SNARE Complex Assembly in Neurosecretory Cells"
**作者**: Takahashi, Y., et al.
**摘要**: 本研究利用特异性NAPG抗体探究神经内分泌细胞中SNARE复合体的组装机制。通过免疫共沉淀和Western blot分析，发现NAPG在囊泡与质膜融合过程中与Syntaxin-1A和SNAP-25存在动态相互作用，提示其在调节神经递质释放中的关键作用。
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2. **文献名称**: "Role of NAPG in Cancer Cell Vesicle Trafficking: Insights from Antibody-Mediated Inhibition"
**作者**: Chen, L., & Rodriguez, M.
**摘要**: 该研究通过开发高亲和力NAPG单克隆抗体，揭示NAPG在肿瘤细胞囊泡运输中的功能。实验表明，抗体阻断NAPG活性可显著抑制癌细胞的EGFR膜定位，并降低其增殖和侵袭能力，为靶向NAPG的癌症治疗提供了潜在策略。
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3. **文献名称**: "Development of a Novel NAPG Autoantibody Assay for Neurological Disorder Diagnosis"
**作者**: Gupta, S., et al.
**摘要**: 研究团队建立了一种检测血清中抗NAPG自身抗体的ELISA方法，发现其在多发性硬化症(MS)患者中阳性率高达32%。该抗体可能通过干扰突触囊泡循环加剧神经炎症，提示NAPG自身免疫反应在MS病理中的潜在作用。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词如“NAPG antibody”、“SNARE complex”或结合具体研究领域(如癌症、神经科学)进行筛选。
The NAPG antibody targets the N-ethylmaleimide-sensitive factor attachment protein gamma (NAPG), a critical component of the SNARE (soluble NSF attachment protein receptor) complex, which mediates intracellular membrane fusion events. NAPG, also known as γ-SNAP, works alongside α- and β-SNAP isoforms to facilitate vesicle trafficking, neurotransmitter release, and organelle maintenance by binding to NSF (N-ethylmaleimide-sensitive fusion protein) and disassembling SNARE complexes post-fusion. This recycling of SNARE proteins is essential for sustained cellular secretion and membrane dynamics.
NAPG antibodies are widely used in neuroscience and cell biology research to study synaptic function, vesicle transport, and membrane fusion mechanisms. They enable detection and localization of NAPG in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of NAPG-associated pathways has been implicated in neurodegenerative disorders (e.g., Alzheimer’s disease) and secretory pathway defects, making these antibodies valuable tools for exploring disease mechanisms. Available as polyclonal or monoclonal forms, NAPG antibodies are typically raised in hosts like rabbits or mice, with validation in knockout models ensuring specificity. Their application extends to drug discovery and functional studies aiming to modulate SNARE-mediated processes.
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