| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Purine nucleoside phosphorylase, PNP, Inosine phosphorylase, Inosine-guanosine phosphorylase, PNP, NP |
| Entrez GeneID | 4860 |
| WB Predicted band size | 32.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PNP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-178 amino acids from the Central region of human PNP. |
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以下是3-4条关于PNP(嘌呤核苷磷酸化酶)抗体的虚构参考文献示例(基于学术文献常见结构，非真实文献)：
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1. **文献名称**: *Autoantibodies against Purine Nucleoside Phosphorylase in Systemic Lupus Erythematosus*
**作者**: Smith A, et al.
**摘要**: 本研究探讨了系统性红斑狼疮(SLE)患者血清中抗PNP抗体的存在及其临床意义。通过ELISA检测发现，约15%的SLE患者存在PNP抗体，且与疾病活动度和肾脏损伤呈正相关，提示其可能作为SLE的新型生物标志物。
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2. **文献名称**: *PNP Deficiency and Autoantibody Production: A Case Study*
**作者**: Chen L, et al.
**摘要**: 报道一例罕见的先天性PNP缺乏症患者，同时检测到高滴度的抗PNP自身抗体。研究提出PNP酶活性缺失可能导致免疫耐受异常，进而触发针对PNP的自身免疫反应，为PNP缺乏症的病理机制提供新视角。
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3. **文献名称**: *Development of a High-Sensitivity Assay for Anti-PNP Antibodies in Neurological Disorders*
**作者**: Gupta R, et al.
**摘要**: 本文开发了一种基于化学发光法的PNP抗体检测技术，并在多发性硬化症(MS)患者队列中验证其灵敏性。结果显示，MS患者中PNP抗体的阳性率显著高于健康对照组，提示其可能参与神经炎症过程。
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4. **文献名称**: *Anti-Purine Nucleoside Phosphorylase Antibodies in Autoimmune Hepatitis*
**作者**: Tanaka K, et al.
**摘要**: 研究分析了自身免疫性肝炎(AIH)患者中抗PNP抗体的分布，发现其与AIH特定亚型(如I型)及糖皮质激素治疗反应相关，可能为AIH的亚类分型提供辅助诊断依据。
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**注**：以上文献为示例性内容，真实文献需通过PubMed、Google Scholar等平台检索关键词(如"PNP antibody"或"purine nucleoside phosphorylase autoantibody")。
**Background of PNP Antibodies**
PNP (purine nucleoside phosphorylase) antibodies are autoantibodies targeting the enzyme PNP, which plays a critical role in purine metabolism by catalyzing the salvage pathway for nucleotide synthesis. PNP deficiency, a rare autosomal recessive disorder, is linked to severe T-cell immunodeficiency due to toxic metabolite accumulation. While PNP deficiency itself is genetic, the presence of anti-PNP antibodies is not typically associated with this condition. Instead, such antibodies are occasionally identified in autoimmune or paraneoplastic contexts.
In autoimmune diseases, anti-PNP antibodies may arise due to molecular mimicry or dysregulated immune responses, though their clinical significance remains poorly characterized. Research suggests potential associations with neurological or systemic autoimmune disorders, but evidence is limited. In cancer, PNP overexpression in tumors might trigger antibody production as part of paraneoplastic syndromes, though this is not well-documented.
Detection of PNP antibodies is primarily exploratory, often via enzyme-linked immunosorbent assays (ELISA) or immunoblotting, but they are not yet established as diagnostic biomarkers. Further studies are needed to clarify their pathogenic role, diagnostic utility, and relevance in specific diseases. Overall, PNP antibodies represent an emerging area of interest in autoimmunity and oncology, warranting deeper investigation into their mechanisms and clinical implications.
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