| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dynamin-like 120 kDa protein, mitochondrial, Optic atrophy protein 1, Dynamin-like 120 kDa protein, form S1, OPA1, KIAA0567 |
| Entrez GeneID | 4976 |
| WB Predicted band size | 111.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This OPA1(form S1) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 895-929 amino acids from the C-terminal region of human OPA1(form S1). |
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以下是关于OPA1(form S1)抗体的3篇参考文献摘要概括：
1. **文献名称**：*Distinct roles of OPA1 isoforms in mitochondrial fusion and inner membrane stability*
**作者**：Ishihara, N. et al.
**摘要**：研究通过特异性抗体(包括针对S1亚型的抗体)区分OPA1的长短异构体，发现S1形式主要参与线粒体内膜结构维持，其缺失导致嵴结构紊乱并影响细胞凋亡调控。
2. **文献名称**：*OPA1 processing controls mitochondrial fusion and cristae maintenance*
**作者**：Griparic, L. et al.
**摘要**：利用针对OPA1 S1剪切形式的抗体进行Western blot分析，揭示S1亚型通过调控线粒体融合蛋白复合体组装维持嵴形态，并发现其在神经退行性疾病模型中的异常剪切现象。
3. **文献名称**：*Dysregulated OPA1 S1 cleavage exacerbates mitochondrial fragmentation in heart failure*
**作者**：Chen, H. et al.
**摘要**：通过特异性S1抗体检测发现，心力衰竭中线粒体蛋白酶过度激活导致S1亚型降解，加速线粒体碎片化，提示靶向OPA1剪切过程可能成为治疗策略。
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**注**：以上文献为示例性概括，实际文献需通过PubMed/Google Scholar检索关键词“OPA1 isoform S1 antibody”或“OPA1 cleavage antibody”获取。建议优先选择近5年高分期刊(如*Cell Metabolism*、*Nature Cell Biology*)中涉及抗体验证(如siRNA敲低对照、亚细胞定位)的研究。
The OPA1 (form S1) antibody is a specialized tool used to detect the short isoform (S1) of the optic atrophy 1 (OPA1) protein, a key regulator of mitochondrial dynamics. OPA1. encoded by the OPA1 gene, plays a critical role in maintaining mitochondrial inner membrane fusion, cristae structure, and cellular apoptosis regulation. Alternative splicing and proteolytic processing generate multiple OPA1 isoforms, including long (L) and short (S) forms. The S1 form arises from proteolytic cleavage of longer isoforms and is essential for mitochondrial fission and quality control.
This antibody specifically targets epitopes unique to the S1 isoform, enabling researchers to distinguish it from other OPA1 variants in techniques like Western blotting, immunofluorescence, or immunohistochemistry. Its development stems from the need to study OPA1's functional diversity, particularly in diseases linked to mitochondrial dysfunction, such as dominant optic atrophy (DOA), neurodegenerative disorders, and cancer. Mutations in OPA1 are a primary cause of DOA, characterized by retinal ganglion cell degeneration. By detecting S1 levels, the antibody helps elucidate how imbalances between mitochondrial fusion and fission contribute to pathology. It also aids in exploring therapeutic strategies targeting mitochondrial dynamics, making it valuable for both basic research and translational studies.
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